香港社区获得性严重急性呼吸综合征冠状病毒2（SARS-CoV-2）B.1.351谱系的早期检测。
Early detection of community acquired of SARS-CoV-2 lineage B.1.351 in Hong Kong.
作者信息
Tsang Alan K L, Mak Gannon C K, Cheng Peter K C, Yip Peter C W, Ng Ken H L, Lam Edman T K, Chan Rickjason C W, Tsang Dominic N C
机构信息
All from Microbiology Division, Public Health Laboratory Services Branch, Centre for Health Protection, Department of Health, 9/F, Public Health Laboratory center, 382 Nam Cheong Street, Shek Kip Mei, Kowloon, Hong Kong Special Administrative Region.
出版信息
J Clin Virol Plus. 2021 Sep;1(3):100029. doi: 10.1016/j.jcvp.2021.100029. Epub 2021 Jun 14.
BACKGROUND
Prior to this report, variants of concern for SARS-CoV-2 were only detected from imported cases in Hong Kong.
OBJECTIVE
Multiple cases of SARS-CoV-2 lineage B.1.351 have been identified in local community. We reported the phylogenetic relationship of these cases.
STUDY DESIGN
SARS-CoV-2 cases were screened for the key non-synonymous substitutions in spike protein by different assays. Preliminary positive cases were further tested by whole genome sequencing.
RESULTS
From Dec 2020 to May 2021, 55 SARS-CoV-2 cases belonged to lineage B.1.351. Among them, eight genomes were clustered together, all of them were local cases with epidemiological link.
CONCLUSIONS
To track variants of SARS-CoV-2 and to allow early implementation of control measures, SARS-CoV-2 genomic surveillance must be consistently performed.
背景
在本报告发布之前，香港仅从输入病例中检测到严重急性呼吸综合征冠状病毒2（SARS-CoV-2）的关注变异株。
目的
在本地社区发现了多例SARS-CoV-2 B.1.351谱系病例。我们报告了这些病例的系统发育关系。
研究设计
通过不同检测方法对SARS-CoV-2病例的刺突蛋白关键非同义替换进行筛查。初步阳性病例进一步进行全基因组测序检测。
结果
2020年12月至2021年5月，55例SARS-CoV-2病例属于B.1.351谱系。其中，8个基因组聚集在一起，所有病例均为有流行病学关联的本地病例。
结论
为追踪SARS-CoV-2变异株并尽早实施控制措施，必须持续开展SARS-CoV-2基因组监测。
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