Department of Molecular Pathology, Shinshu University School of Medicine, Asahi, Matsumoto, Japan.
Department of Laboratory Medicine, JA North Alps Medical Center Azumi Hospital, Ikeda-town, Kitaazumi-gun, Japan.
Pathol Int. 2022 May;72(5):300-306. doi: 10.1111/pin.13220. Epub 2022 Mar 9.
Bronchiolar adenoma/ciliated muconodular papillary tumor is a lung neoplasm exhibiting various degrees of proximal and distal bronchiolar differentiation. Here, we evaluated distribution of MUC5AC and MUC5B in bronchiolar adenoma/ciliated muconodular papillary tumor for comparison with that seen in normal respiratory tract. In normal respiratory tract, MUC5AC was mainly distributed in large bronchi, while MUC5B was distributed in bronchi, bronchioles, and submucosal glands. In bronchiolar adenoma/ciliated muconodular papillary tumor, MUC5AC was primarily distributed in luminal cells of large airspaces, and MUC5B was distributed in luminal cells of small airspaces and mucinous glands, in addition to large airspaces, regardless of distal or proximal differentiation. In particular, MUC5B was distributed in non-mucinous club and ciliated cells in both the normal respiratory tract and bronchiolar adenoma/ciliated muconodular papillary tumor. These results indicate that MUC5AC and MUC5B distribution in bronchiolar adenoma/ciliated muconodular papillary tumor is similar to that seen in normal respiratory tract, suggestive of organoid differentiation simulating the normal lung.
细支气管腺瘤/纤毛黏液结节乳头状肿瘤是一种具有不同程度近端和远端细支气管分化的肺肿瘤。在此，我们评估了细支气管腺瘤/纤毛黏液结节乳头状肿瘤中 MUC5AC 和 MUC5B 的分布，以便与正常呼吸道进行比较。在正常呼吸道中，MUC5AC 主要分布于大气道，而 MUC5B 则分布于支气管、细支气管和黏膜下腺。在细支气管腺瘤/纤毛黏液结节乳头状肿瘤中，MUC5AC 主要分布于大气道腔的细胞中，而 MUC5B 则分布于小气道腔和黏液腺的细胞中，除了大气道之外，无论分化是近端还是远端。特别是，MUC5B 分布于正常呼吸道和细支气管腺瘤/纤毛黏液结节乳头状肿瘤中的非黏液性纤毛细胞和纤毛细胞中。这些结果表明，细支气管腺瘤/纤毛黏液结节乳头状肿瘤中 MUC5AC 和 MUC5B 的分布与正常呼吸道中所见相似，提示其具有模拟正常肺的器官样分化。
