Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, MN, US.
Department of Laboratory Medicine and Pathology, Mayo Clinic, Scottsdale, AZ, US.
Am J Clin Pathol. 2023 Dec 1;160(6):555-560. doi: 10.1093/ajcp/aqad090.
Bronchiolar adenoma/ciliated muconodular papillary tumor (BA/CMPT) and sclerosing pneumocytoma (SP) are both rare and morphologically unique peripheral lung tumors with indolent behavior. These tumors have not been previously described as showing overlapping morphologic features and are generally genetically distinct.
Two cases were recently encountered that show hybrid morphologic features between BA/CMPT and SP, and the morphology and immunophenotype are described in detail.
Both cases showed interstitial round cells typical of SP (TTF1+, EMA+), as well as areas more typical of BA/CMPT. One case showed BRAFV600E expression in the BA/CMPT areas but not in the SP-like cells.
Although it is possible that these cases represent collision tumors or are examples of unusual metaplastic epithelial changes in SP, they also raise the possibility that these 2 entities could occasionally coexist in true hybrid tumors.
细支气管腺瘤/纤毛黏液乳头状肿瘤（BA/CMPT）和硬化性肺细胞瘤（SP）均为罕见且形态独特的肺部外周肿瘤，具有惰性行为。这些肿瘤以前没有被描述为表现出重叠的形态特征，并且通常在基因上是不同的。
最近遇到了两个病例，它们表现出 BA/CMPT 和 SP 之间的混合形态特征，并详细描述了形态学和免疫表型。
两个病例均显示出典型的 SP 的间质圆形细胞（TTF1+，EMA+），以及更典型的 BA/CMPT 区域。一个病例在 BA/CMPT 区域显示 BRAFV600E 表达，但在 SP 样细胞中没有表达。
尽管这些病例可能代表碰撞肿瘤，或者是 SP 中罕见的上皮化生改变的例子，但它们也提出了这两种实体偶尔可能在真正的混合肿瘤中共存的可能性。
