脂肪组织来源的基质/干细胞对肿瘤和创伤的反应：患者年龄的评估。
Adipose-Derived Stromal/Stem Cell Response to Tumors and Wounds: Evaluation of Patient Age.
机构信息
Department of Biological Engineering, Louisiana State University, Baton Rouge, Louisiana, USA.
University of North Texas Health Sciences Center, Fort Worth, Texas, USA.
出版信息
Stem Cells Dev. 2022 Oct;31(19-20):579-592. doi: 10.1089/scd.2021.0280. Epub 2022 May 16.
Tumors were characterized as nonhealing wounds by Virchow in 1858 and Dvorak in 1986. Since then, researchers have analyzed tumors from a new perspective. The parallels between tumorigenesis and physiological wound healing can provide a new framework for developing antitumor therapeutics. One commonality between tumors and wounds is the involvement of the stromal environment, particularly adipose stromal/stem cells (ASCs). ASCs exhibit dual functions, in which they stimulate tumor progression and assist in tissue repair and regeneration. Numerous studies have focused on the role of ASCs in cancer and wound healing, but none to date has linked age, cancer, and wound healing. Furthermore, very few studies have focused on the role of donor-specific characteristics of ASCs, such as age and their role in facilitating ASC behavior in cancer and wound healing. This review article is designed to provide important insights into the impact of donor age on ASC tumor and wound response and their role in facilitating ASC behavior in cancer and wound healing.
1858 年，Virchow 将肿瘤描述为非愈合性伤口，1986 年 Dvorak 也有同样的观点。此后，研究人员从新的角度分析了肿瘤。肿瘤发生与生理伤口愈合之间存在诸多相似之处，这为开发抗肿瘤治疗方法提供了新的框架。肿瘤和伤口的一个共同特征是涉及基质环境，特别是脂肪基质/干细胞（ASCs）。ASCs 具有双重功能，既能刺激肿瘤进展，又能协助组织修复和再生。许多研究都集中在 ASCs 在癌症和伤口愈合中的作用上，但迄今为止，还没有将年龄、癌症和伤口愈合联系起来的研究。此外，很少有研究关注 ASC 的供体特异性特征（如年龄）及其在促进 ASC 在癌症和伤口愈合中行为的作用。本文旨在深入了解供体年龄对 ASC 肿瘤和伤口反应的影响，以及其在促进 ASC 在癌症和伤口愈合中的行为的作用。
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