Dhiman Vikas, Trushna Tanwi, Raj Dharma, Tiwari Rajnarayan Ramshankar
Department of Environmental Health and Epidemiology, ICMR-National Institute for Research in Environmental Health (NIREH), Bhopal, India.
Department of Biostatistics and Bioinformatics, ICMR-National Institute for Research in Environmental Health (NIREH), Bhopal, India.
Int J Environ Health Res. 2023 Aug;33(8):733-750. doi: 10.1080/09603123.2022.2047903. Epub 2022 Mar 9.
Current evidence shows inconsistencies about ambient air pollution (AAP) exposure as a risk factor for Parkinson's disease (PD). We performed meta-analyses to estimate the pooled risk of PD due to AAP exposure. We performed a systematic search in PubMed, Google Scholar, The Cochrane Library, and J-GATEPLUS databases for peer-reviewed epidemiological studies reporting the risk of PD due to exposure to PM, PM, O, CO, NO, NO and SO; from the beginning until October 2021. The pooled odds ratio (OR) for the effect of NO (per 1 μg/m) and O (per 1 ppb) on PD was 1.01[95% CI: 1.00,1.02; = 69% ( = .01)] and 1.01 [95% CI: 1.00,1.02; = 66% ( = .03)], respectively. The ORs for the effects of PM (per 1 µg/m) and CO (per 1 ppm) on PD were 1.01 [95% CI: .99,1.03; = 40%] and 1.64 [95% CI: .96,2.78; = 75% (= .01)], respectively. The study showed the adverse roles of NO, O, PM and CO in increasing the risk for PD.
目前的证据显示，关于环境空气污染（AAP）暴露作为帕金森病（PD）的一个风险因素存在不一致之处。我们进行了荟萃分析，以估计因AAP暴露导致PD的合并风险。我们在PubMed、谷歌学术、考克兰图书馆和J-GATEPLUS数据库中进行了系统检索，查找截至2021年10月报道因接触PM、PM、O、CO、NO、NO和SO导致PD风险的同行评审流行病学研究。NO（每1μg/m）和O（每1 ppb）对PD影响的合并比值比（OR）分别为1.01[95%置信区间：1.00,1.02；I² = 69%（P = 0.01）]和1.01 [95%置信区间：1.00,1.02；I² = 66%（P = 0.03）]。PM（每1µg/m）和CO（每1 ppm）对PD影响的OR分别为1.01 [95%置信区间：0.99,1.03；I² = 40%]和1.64 [95%置信区间：0.96,2.78；I² = 75%（P = 0.01）]。该研究表明NO、O、PM和CO在增加PD风险方面的不良作用。
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