Coderre Terence J, Grimes Robert W, Melzack Ronald
Department of Psychology, McGill University, 1205 Docteur Penfield Ave., Montreal, Que. H3A 1B1 Canada.
Pain. 1986 Jul;26(1):61-84. doi: 10.1016/0304-3959(86)90174-0.
This paper examines evidence which suggests that the self-mutilation of deafferented limbs exhibited by laboratory animals is a response to pain or dysesthesia and is therefore an adequate model of chronic pain. Evidence from studies using physiological, pharmacological and behavioral methods provides strong support that autotomy reflects chronic pain. New evidence presented in this paper demonstrates that specific treatments can be used to manipulate the extent of autotomy, causing increases or decreases, as well as restricting it to specific parts of a denervated foot. This evidence argues that autotomy scores are an appropriate measure of the degree of pain or dysesthesia which results from the deafferentation of a limb.
本文考察了相关证据，这些证据表明实验动物表现出的去传入肢体自残行为是对疼痛或感觉异常的一种反应，因此是慢性疼痛的一个合适模型。使用生理学、药理学和行为学方法进行的研究证据有力支持了自残反映慢性疼痛这一观点。本文提出的新证据表明，特定治疗方法可用于控制自残程度，使其增加、减少，或将其限制在去神经支配足部的特定部位。这一证据表明，自残评分是衡量肢体去传入后所导致疼痛或感觉异常程度的一种合适指标。
