de Morais C F, Lopes E A, Bisi H, Alves V A, de Macedo Santos R T
Pathol Res Pract. 1986 May;181(2):175-9. doi: 10.1016/S0344-0338(86)80007-3.
Pancreatic tissue from 5 children with congenital heart disease (CHD) with morphological alterations of the endocrine components at autopsy were compared in a double-blind semiquantitative study, which included light microscopy and immunocytochemistry, to pancreatic tissue of 5 children of similar age but without CHD. Hyperplasia and hypertrophy of islets of Langerhans, scattered endocrine cells within the exocrinic acini, cluster of endocrine cells budding from ductular epithelium or within interlobular connective tissue, and hyperplasia of ductular epithelium were found to be present in the patients with congenital cardiac defects. The observed findings resembled those present in a surgically resected pancreas from a child with clinically overt nesidioblastosis. Although this study suggests a higher incidence of endocrine pancreas disturbances in certain types of CHD, the clinical significance of these morphological alterations will require further studies.
在一项双盲半定量研究中，对5名先天性心脏病（CHD）患儿尸检时内分泌成分有形态学改变的胰腺组织，与5名年龄相仿但无CHD的儿童的胰腺组织进行了比较，该研究包括光学显微镜检查和免疫细胞化学。结果发现，先天性心脏缺陷患者存在朗格汉斯岛增生和肥大、外分泌腺泡内散在的内分泌细胞、从导管上皮或小叶间结缔组织中萌出的内分泌细胞簇，以及导管上皮增生。观察到的结果与一名临床明显的胰岛母细胞瘤患儿手术切除的胰腺中的结果相似。虽然这项研究表明某些类型的CHD中内分泌胰腺紊乱的发生率较高，但这些形态学改变的临床意义还需要进一步研究。
