Zhang Lina, Wu Di, Xu Mingyue, Bian Yonghui, Wang Youcun, Gao Guangkai, Sun Qing
Department of Special Medicine, School of Basic Medicine, Qingdao University, Qingdao, Shandong 266071, China.
Department of Military and Special Medicine, No. 971 Hospital of the People's Liberation Army Navy, Qingdao, Shandong 266071, China.
Chin Med J (Engl). 2022 Feb 15;135(13):1539-44. doi: 10.1097/CM9.0000000000001942.
Carbon monoxide (CO) poisoning remains a major cause of accidental injuries and multiple studies have indicated that CO is also associated with significantly severe or long-term toxicity to the central nervous system. Given that CO poisoning causes serious morbidity and mortality, a better understanding of epidemiological features and clinical characteristics of acute CO poisoning in China is crucial.
We collected the clinical data of acute CO poisoning in patients between November 2019 and April 2020 across Shandong province, China and analyzed its characteristics focusing on the weekly amount and the severity of the confirmed cases.
A total number of 21,088 acute CO poisoning cases were diagnosed. The overall incidence of acute CO poisoning was approximately 0.021%. On severity rankings, 63% of confirmed cases (n = 13,378) were mild, 27% (n = 5635) were moderate, and 10% (n = 2075) were severe. Interestingly, the coastal cities had more confirmed cases than the inland/suburban areas in Shandong. Meanwhile, the number of confirmed cases was negatively correlated with the local mean daily temperature (P = 0.0167).
Mild acute CO poisoning cases accounted for the majority of all confirmed cases during the winter of 2019. In Shandong province, which is located in east China, residents of the coastal cities are more susceptible to CO poisoning than residents of inland cities.
一氧化碳（CO）中毒仍然是意外伤害的主要原因，多项研究表明，CO还与中枢神经系统的严重或长期毒性显著相关。鉴于CO中毒会导致严重的发病率和死亡率，更好地了解中国急性CO中毒的流行病学特征和临床特点至关重要。
我们收集了2019年11月至2020年4月期间中国山东省急性CO中毒患者的临床数据，并重点分析了确诊病例的每周数量和严重程度。
共诊断出21088例急性CO中毒病例。急性CO中毒的总体发病率约为0.021%。在严重程度排名中，63%的确诊病例（n = 13378）为轻度，27%（n = 5635）为中度，10%（n = 2075）为重度。有趣的是，山东沿海城市的确诊病例比内陆/郊区多。同时，确诊病例数与当地日平均气温呈负相关（P = 0.0167）。
2019年冬季，轻度急性CO中毒病例占所有确诊病例的大多数。在中国东部的山东省，沿海城市居民比内陆城市居民更容易发生CO中毒。
