Hu Bin, Hu Haibo, Pu Chuan, Wei Zheng, Wang Qiuhong, Kuang Haixue
National Engineering Research Center for Modernization of Traditional Chinese Medicine-Hakka Medical Resources Branch, School of Pharmacy, Gannan Medical University, Ganzhou, China.
Key Laboratory of Chinese Materia Medica, School of Pharmacy, Heilongjiang University of Chinese Medicine, Harbin, China.
Nat Prod Res. 2022 Dec;36(23):5940-5949. doi: 10.1080/14786419.2022.2047045. Epub 2022 Mar 9.
Three new flavonoid glycosides, Dasuanxinoside F-H (), were isolated from the aerial parts of , together with eight known compounds which were firstly reported in this plant, including three flavonoid glycosides () and five phenylethanoid glycosides (). Their structures were identified by UV-vis, IR, 1D and 2D NMR spectra, as well as HR-ESI-MS analyses. The inhibitory effect of the isolated compounds on platelet aggregation induced by adenosine diphosphate (ADP) was evaluated . The results showed that most compounds displayed different degrees of inhibition. Among them, , , and exhibited the strongest activity on platelet aggregation.
从[植物名称]地上部分分离出三种新的黄酮苷，即大蒜新苷F-H（），以及八种首次在该植物中报道的已知化合物，包括三种黄酮苷（）和五种苯乙醇苷（）。通过紫外可见光谱、红外光谱、一维和二维核磁共振光谱以及高分辨电喷雾电离质谱分析确定了它们的结构。评估了分离出的化合物对二磷酸腺苷（ADP）诱导的血小板聚集的抑制作用。结果表明，大多数化合物表现出不同程度的抑制作用。其中，[化合物名称1]、[化合物名称2]、[化合物名称3]和[化合物名称4]对血小板聚集表现出最强的活性。
