Electro-Materials Research Laboratory, Centre for Nanoscience and Technology, Pondicherry University, Puducherry, India.
School of Chemical Engineering, Yeungnam University, Gyeongson, Republic of Korea.
J Biomater Sci Polym Ed. 2022 Jul;33(10):1256-1268. doi: 10.1080/09205063.2022.2048453. Epub 2022 Mar 9.
With the thought and strong hope of uniqueness and challenging characteristic highlights and importance of nanofibrous mats (NFMs) along with cyclodextrins (CDs) that having a significant opportunity, chances and handling a vital role in hostile to bacterial activities. For the most part, CDs are utilized to upgrade the antibacterial activity through the improvement of solubility, stability, and etc., to any molecule which can bring inside the CDs cavity the formation of inclusion complexes. Polymer-mediated electrospun nanofibrous mats (PAN NFMs) are utilized as a nanocarrier for antibacterial activity in this article, utilizing nortriptyline (NP) as a reference molecule. As a result, NP forms an inclusion complex with β-Cyclodextrin (β-CD). As a result, the PAN NFMs are able to absorb it, thereby consolidating the complex NP on the nanofibrous surface. Additionally, the soaking of PAN NFMs in NP solution without β-CD was performed for comparison. To characterize the nanofibrous mats of NP/PAN and NP:β-CD-ICs/PAN NFMs, UV absorption, FTIR, Raman, XRD, and SEM techniques were used. The antibacterial activity of NP and NP:β-CD-ICs have been tried against positive control antibiotics by the disc diffusion method. Thus, the action has been improved for NP:β-CD-ICs/PAN NFMs over NP/PAN NFMs because of the solubility upgraded for the NP by the complexation of β-CD.
带着独特性和挑战性特点的思想和强烈的希望，突出和强调了纳米纤维垫（NFMs）与环糊精（CDs）的重要性，它们在抗菌活性方面具有重要的机会、可能性和关键作用。在大多数情况下，CD 被用于通过提高溶解度、稳定性等来增强抗菌活性，将任何可以进入 CD 腔的分子形成包合物。本文利用聚合物介导的电纺纳米纤维垫（PAN NFMs）作为抗菌活性的纳米载体，以去甲替林（NP）作为参考分子。结果，NP 与β-环糊精（β-CD）形成包合物。因此，PAN NFMs 能够吸收它，从而将复合 NP 固定在纳米纤维表面上。此外，还进行了 PAN NFMs 在不含 β-CD 的 NP 溶液中的浸泡实验，以作对比。为了对 NP/PAN 和 NP:β-CD-ICs/PAN NFMs 进行纳米纤维垫的表征，采用了紫外吸收、FTIR、拉曼、XRD 和 SEM 技术。通过圆盘扩散法，尝试了 NP 和 NP:β-CD-ICs 对阳性对照抗生素的抗菌活性。因此，由于β-CD 的络合作用提高了 NP 的溶解度，NP:β-CD-ICs/PAN NFMs 的作用优于 NP/PAN NFMs。
