Aytac Zeynep, Yildiz Zehra Irem, Kayaci-Senirmak Fatma, Tekinay Turgay, Uyar Tamer
Institute of Materials Science & Nanotechnology, UNAM-National Nanotechnology Research Center, Bilkent University, Ankara 06800, Turkey.
Life Sciences Application and Research Center, Gazi University, Ankara 06830, Turkey; Department of Medical Biology and Genetics, Faculty of Medicine, Gazi University, Ankara 06560, Turkey.
Food Chem. 2017 Sep 15;231:192-201. doi: 10.1016/j.foodchem.2017.03.113. Epub 2017 Mar 23.
The volatility and limited water solubility of linalool is a critical issue to be solved. Here, we demonstrated the electrospinning of polymer-free nanofibrous webs of cyclodextrin/linalool-inclusion complex (CD/linalool-IC-NFs). Three types of modified cyclodextrin (HPβCD, MβCD, and HPγCD) were used to electrospin CD/linalool-IC-NFs. Free-standing CD/linalool-IC-NFs facilitate maximum loading of linalool up to 12% (w/w). A significant amount of linalool (45-89%) was preserved in CD/linalool-IC-NFs, due to enhancement in the thermal stability of linalool by cyclodextrin inclusion complexation. Remarkably, CD/linalool-IC-NFs have shown fast-dissolving characteristics in which these nanofibrous webs dissolved in water within two seconds. Furthermore, linalool release from CD/linalool-IC-NFs inhibited growth of model Gram-negative (E. coli) and Gram-positive (S. aureus) bacteria to a great extent. Briefly, characteristics of liquid linalool have been preserved in a solid nanofiber form and designed CD/linalool-IC-NFs confer high loading capacity, enhanced shelf life and strong antibacterial activity of linalool.
芳樟醇的挥发性和有限的水溶性是亟待解决的关键问题。在此，我们展示了环糊精/芳樟醇包合物（CD/芳樟醇-IC-NFs）无聚合物纳米纤维网的静电纺丝过程。使用三种改性环糊精（HPβCD、MβCD和HPγCD）来静电纺丝CD/芳樟醇-IC-NFs。自立式CD/芳樟醇-IC-NFs能够实现高达12%（w/w）的芳樟醇最大负载量。由于环糊精包合作用提高了芳樟醇的热稳定性，大量芳樟醇（45-89%）得以保存在CD/芳樟醇-IC-NFs中。值得注意的是，CD/芳樟醇-IC-NFs具有快速溶解的特性，这些纳米纤维网在两秒内即可溶于水。此外，CD/芳樟醇-IC-NFs释放的芳樟醇在很大程度上抑制了革兰氏阴性菌（大肠杆菌）和革兰氏阳性菌（金黄色葡萄球菌）的生长。简而言之，液态芳樟醇的特性以固体纳米纤维的形式得以保留，所设计的CD/芳樟醇-IC-NFs赋予了芳樟醇高负载能力、延长的保质期和强大的抗菌活性。
