Department of Industrial Chemistry, Alagappa University, Karaikudi 630002, Tamil Nadu, India.
Department of Chemistry, College of Science, King Saud University, Riyadh 11451, Saudi Arabia.
Spectrochim Acta A Mol Biomol Spectrosc. 2021 Mar 15;249:119308. doi: 10.1016/j.saa.2020.119308. Epub 2020 Dec 15.
Here, we prepared the solid inclusion complexes between Caffeic acid (CA) and Cyclodextrins (β- and γ-CDs) (CA/CDs) that were effectively embedded into Poly (vinyl alcohol) (PVA) electrospun nanofibers via electrospinning technique to enhanced solubility and antibacterial activity. In tested Cyclodextrins are β-and γ-CDs with CA in the ratio of 1:1 resulting in the formation of CA/CDs by co-precipitation method. The physical properties of CA/CDs were examined by FT-IR, UV, and Raman Spectroscopy. The phase solubility test showed a much higher solubility of CA due to inclusion complexes (ICs). Furthermore, CA/β-CD and CA/γ-CD perfected achieved 0.70:1 and 0.80:1 the molar ratio of ICs, confirmed by NMR studies. The fiber size distribution, average diameter, and morphology features were evaluated by SEM analysis. The dissolution profile of PVA/CA and PVA/CA/CDs were tested within 150 min, resulting in CA dissolved in PVA/CA/CDs slightly higher than PVA/CA nanofibers due to enhanced solubility of ICs. Moreover, PVA/CA/CDs exhibit high antibacterial activity against gram-positive bacteria of E-Coli and gram-negative bacteria of S. aureus. Finally, these results suggest that PVA/CA/CDs may be promising materials for active food packaging applications.
在这里，我们制备了咖啡酸（CA）和环糊精（β-和γ-CDs）之间的固体包合物（CA/CDs），通过静电纺丝技术将其有效地嵌入到聚乙烯醇（PVA）电纺纳米纤维中，以提高其溶解度和抗菌活性。在测试的环糊精中，β-CDs 和 γ-CDs 与 CA 的比例为 1:1，通过共沉淀法形成 CA/CDs。通过傅里叶变换红外光谱（FT-IR）、紫外光谱（UV）和拉曼光谱（Raman Spectroscopy）对 CA/CDs 的物理性质进行了研究。相溶解度测试表明，由于包含复合物（ICs），CA 的溶解度大大提高。此外，CA/β-CD 和 CA/γ-CD 的摩尔比分别达到了 0.70:1 和 0.80:1，通过 NMR 研究得到了证实。通过扫描电子显微镜（SEM）分析评估了纤维的尺寸分布、平均直径和形貌特征。在 150 分钟内测试了 PVA/CA 和 PVA/CA/CDs 的溶解曲线，结果表明由于 ICs 的溶解度提高，PVA/CA/CDs 中 CA 的溶解量略高于 PVA/CA 纳米纤维。此外，PVA/CA/CDs 对革兰氏阳性菌大肠杆菌和革兰氏阴性菌金黄色葡萄球菌具有高抗菌活性。最后，这些结果表明，PVA/CA/CDs 可能是用于活性食品包装应用的有前途的材料。
