This systematic review aimed to synthesize the current evidence on the feasibility of volitional reaction time (RT) tests to evaluate the information processing abilities of athletes. Four databases were searched, and, finally, 38 studies exploring the reliability, validity, or sensitivity of RT tests were included. Seven studies explored the reliability, which ranged from poor to excellent, while only three studies explored the validity of RT tests. The most important downside of the majority of the implemented RT tests is their nonspecific nature (i.e., stimulus and response did not resemble the sports actions). Sports scientists should focus on developing RT tests that are specific for each sport and refine the testing procedures to obtain accurate, reproducible, and sensitive measurements of RT.