Aljuhani Wazzan S, Alanazi Abdullah M, Alghafees Mohammad A
Department of Orthopedic Surgery, National Guard Hospital, Riyadh, KSA.
College of Medicine, King Saud bin Abdulaziz University for Health Sciences, Riyadh, KSA.
J Taibah Univ Med Sci. 2020 Dec 1;16(1):77-85. doi: 10.1016/j.jtumed.2020.11.001. eCollection 2021 Feb.
The geographical incidence of tumours is usually influenced by the environment, race, and culture. This study aimed to report the incidence and differences in tumour type, site of origin, and mortality across gender, regions, age, and the different characteristics of tumour types.
This retrospective cohort study included all patients diagnosed with primary bone sarcomas from January 1, 2013, to December 31, 2017. Frequencies and percentages were generated for categorical variables. Means and standard deviations were calculated for quantitative variables. A chi-squared test was used to detect differences among categorical variables. Student-t, ANOVA, and Tukey tests were used to detect differences among quantitative variables. Lastly, we calculated the incidence of each tumour type.
Of 451 patients, 248 (55%) had osteosarcomas; 160 (35.5%) had Ewing's sarcoma, and 43 (9.5%) had chondrosarcoma. The incidence was 1.56 cases per 1,000,000 per year for osteosarcoma, 0.95 cases per 1,000,000 per year for Ewing's sarcoma, and 0.27 cases per million per year for chondrosarcoma. The three-year survival rate was 82.30%. Significant differences in tumour type, origin site, and three-year survival across age and gender were detected. Similarly, significant differences were also noted in origin site, grade, basis of diagnosis, and lateralisation across tumour types.
In our study, the observed bone sarcoma incidence rates were lower than the ones reported worldwide. Understanding the pattern of tumour behaviour in the region will help develop a risk and response-based treatment plan for early decision-making.
肿瘤的地理发病率通常受环境、种族和文化影响。本研究旨在报告肿瘤类型、起源部位以及不同性别、地区、年龄和肿瘤类型特征的死亡率的发病率及差异。
这项回顾性队列研究纳入了2013年1月1日至2017年12月31日期间所有诊断为原发性骨肉瘤的患者。分类变量采用频率和百分比表示。定量变量计算均值和标准差。采用卡方检验检测分类变量之间的差异。采用学生t检验、方差分析和Tukey检验检测定量变量之间的差异。最后，我们计算了每种肿瘤类型的发病率。
451例患者中，248例（55%）患有骨肉瘤；160例（35.5%）患有尤因肉瘤，43例（9.5%）患有软骨肉瘤。骨肉瘤的发病率为每年每100万人1.56例，尤因肉瘤为每年每100万人0.95例，软骨肉瘤为每年每百万0.27例。三年生存率为82.30%。在年龄和性别方面，肿瘤类型、起源部位和三年生存率存在显著差异。同样，在起源部位、分级、诊断依据和肿瘤类型的侧别方面也存在显著差异。
在我们的研究中观察到的骨肉瘤发病率低于全球报告的发病率。了解该地区肿瘤行为模式将有助于制定基于风险和反应的治疗计划，以便早期决策。
