Department of Pathology and Microbiology, Faculty of Medicine, Jordan University of Science and Technology, Irbid 22110, Jordan.
Department of Physiology and Biochemistry, Faculty of Medicine, Jordan University of Science and Technology, Irbid 22110, Jordan.
Medicina (Kaunas). 2022 Jan 27;58(2):198. doi: 10.3390/medicina58020198.
: Sarcomas are rare malignant tumors of mesenchymal origin. Their low prevalence and histological heterogeneity make their diagnosis a challenging task. To the best of our knowledge, the epidemiology of soft tissue sarcomas (STSs) was not well studied in Jordan. This study thus aimed to determine STS epidemiologic trends at King Abdullah University Hospital (KAUH); a tertiary hospital that provides cancer healthcare for 70% of the population in Irbid Governorate, North Jordan. The findings of this study will provide a good reference point of the burden of STSs in Jordan and the Middle East region. : All cases with confirmed STS diagnoses who attended KAUH from January 2003 until December 2018 were included in the initial analysis. Bone sarcomas, gastrointestinal stromal tumors and uterine sarcomas were not included in the study. Information collected from the pathology reports and electronic medical records was used to determine STS prevalence, incidence rate, age and gender distributions, histological types and anatomic location. Cases were reviewed by three pathologists with interest in soft tissue tumors. The findings were compared with literature. : In total, 157 STS cases were reported (1.9% of cancers diagnosed at KAUH during the 16-year study period). Crude annual incidence rate (IR) per 100,000 person-years ranged from 0.48 in 2015 to 1.83 in 2011 (average = 1.04). Age-standardized IR (ASR) was 1.37. Male:female ratio was 1.3:1. Median age was 39 years. Age ranged from <1 year to 90 years. Overall STS rates increased with age. The most common histological types were liposarcoma (19%), rhabdomyosarcoma (17%) and leiomyosarcoma (10%). The most common anatomic location was the extremity (40.1%), followed by the trunk (14.7%), then head and neck (10.8%). : STSs are rare in North Jordan. A slight increase in their incidence was identified during the study period similar to global trends. The collection of relevant data on established risk factors along with a broader scale evaluation of the epidemiology of STS in the Middle East region is recommended to better evaluate disease burden and trends.
: 肉瘤是一种罕见的间叶来源的恶性肿瘤。它们的低发病率和组织学异质性使得诊断具有挑战性。据我们所知，约旦的软组织肉瘤 (STS) 流行病学尚未得到很好的研究。因此，本研究旨在确定在约旦北部伊尔比德省为 70%人口提供癌症保健的三级医院阿卜杜拉国王大学医院 (KAUH) 的 STS 流行病学趋势。本研究的结果将为约旦和中东地区 STS 负担提供一个很好的参考点。: 本研究纳入了 2003 年 1 月至 2018 年 12 月在 KAUH 就诊并确诊为 STS 的所有患者。本研究未纳入骨肉瘤、胃肠道间质瘤和子宫肉瘤。从病理报告和电子病历中收集的信息用于确定 STS 的患病率、发病率、年龄和性别分布、组织学类型和解剖部位。由三位对软组织肿瘤感兴趣的病理学家对病例进行了回顾。研究结果与文献进行了比较。: 共报告了 157 例 STS 病例（在 16 年的研究期间，KAUH 诊断出的癌症的 1.9%）。粗发病率（IR）为每年每 100,000 人 0.48 至 1.83 人（平均为 1.04）。年龄标准化发病率（ASR）为 1.37。男女比例为 1.3:1。中位年龄为 39 岁。年龄从<1 岁到 90 岁不等。总体 STS 发病率随年龄增长而增加。最常见的组织学类型是脂肪肉瘤（19%）、横纹肌肉瘤（17%）和平滑肌肉瘤（10%）。最常见的解剖部位是四肢（40.1%），其次是躯干（14.7%），然后是头颈部（10.8%）。: 约旦北部的 STS 较为罕见。在此期间，发病率略有增加，与全球趋势相似。建议收集有关既定危险因素的相关数据，并对中东地区 STS 的流行病学进行更广泛的评估，以更好地评估疾病负担和趋势。
