Department of Nephrology, The First Affiliated Hospital, Sun Yat-sen University and Key Laboratory of Nephrology, Ministry of Health, 58th, Zhongshan Road II, Guangzhou, 510080, Guangdong Province, China.
BMC Nephrol. 2022 Mar 9;23(1):99. doi: 10.1186/s12882-022-02723-9.
The aims of this study were to investigate the prevalence and the influence factors of gastrointestinal symptoms, and its association with the quality of life (QOL) in peritoneal dialysis (PD) patients.
Continuous ambulatory PD patients (CAPD) who followed up in our PD center between March 2016 and December 2017 were enrolled in this cross-sectional study. Gastrointestinal symptom rating scale (GSRS) was used to evaluate gastrointestinal symptoms. The related clinical data were also collected. Multiple linear regression analysis was test for the influence factors associated with score of GSRS and QOL.
This study included 471 CAPD patients. The mean age was 48.5±13.9 years, 53.9% were male and 15.1% with diabetic nephropathy. The median duration of PD was 37.3 (17.566.5) months. The median score of GSRS was 1.2(1.11.3) scores. Totally 82.2% (n=387) CAPD patients had at least one gastrointestinal symptom. Higher glycosylated hemoglobin, higher score of depression, lower diastolic blood pressure, urine output, score of instrumental activities of daily living scale and more amount of pills per day were independently associated with higher score of GSRS (all P<0.05). Score of dyspepsia and eating dysfunction were independently associated with worse score of QOL and physical health (all P<0.05).
Gastrointestinal symptoms were common but not serious in CAPD patients. Glycemic control, depression, blood pressure, urine output, activity of daily life and amount of pills were all associated with gastrointestinal symptoms. Moreover, gastrointestinal symptoms were correlated with QOL of PD patients.
本研究旨在探讨胃肠道症状的患病率及其影响因素，并探讨其与腹膜透析（PD）患者生活质量（QOL）的关系。
本横断面研究纳入了 2016 年 3 月至 2017 年 12 月在我院 PD 中心随访的连续非卧床 PD 患者。采用胃肠道症状评分量表（GSRS）评估胃肠道症状，收集相关临床资料。采用多元线性回归分析探讨与 GSRS 评分和 QOL 相关的影响因素。
本研究共纳入 471 例 CAPD 患者，年龄（48.5±13.9）岁，男性占 53.9%，糖尿病肾病占 15.1%。PD 病程中位数为 37.3（17.566.5）个月，GSRS 评分为 1.2（1.11.3）分。共有 82.2%（n=387）的 CAPD 患者存在至少一种胃肠道症状。较高的糖化血红蛋白、较高的抑郁评分、较低的舒张压、尿输出量、工具性日常生活活动量表评分和每日服药量与 GSRS 评分较高独立相关（均 P<0.05）。消化不良和饮食障碍评分与 QOL 和身体健康评分较差独立相关（均 P<0.05）。
胃肠道症状在 CAPD 患者中较为常见，但并不严重。血糖控制、抑郁、血压、尿输出量、日常生活活动和服药量均与胃肠道症状相关。此外，胃肠道症状与 PD 患者的 QOL 相关。
