Department of Pharmacology and Clinical Pharmacy, School of Pharmacy, College of Health Sciences, Addis Ababa University, Addis Ababa, Ethiopia.
Department of Pharmacology and Clinical Pharmacy, School of Pharmacy, College of Health Sciences, Addis Ababa University, Addis Ababa, Ethiopia
BMJ Open. 2022 Mar 9;12(3):e054778. doi: 10.1136/bmjopen-2021-054778.
This study aimed to determine the prevalence, categories and predictors of drug-related hospitalisation (DRH) among patients visiting emergency departments of Addis Ababa city hospitals, Ethiopia.
A multicentre prospective observational study was conducted through patients' interview and chart review.
The study was undertaken in three tertiary care hospitals in Addis Ababa, Ethiopia.
A total of 423 patients fulfilling the inclusion criteria were included.
Prevalence and preventability of DRH, categories of drug-related problems causing DRH, medications and diseases involved in DRH, and factors significantly associated with DRH.
More than half of the patients (216, 51.1%) were female. The mean age (SD) was 47.50 (±17.21) years. The mean length of hospital stay (SD) was 10.29 (±8.99) days. Nearly 60% (249) of them were hospitalised due to drug-related problems, of which 87.8% were preventable. The cause for hospitalisation for more than half (130, 53%) of them was a failure to receive drugs, and 37.85 (94) patients were categorised as untreated indications. Age ≥65 years (adjusted OR (AOR)=7.451, 95% CI: 1.889 to 29.397), tertiary educational level (AOR=0.360, 95% CI: 0.141 to 0.923), participants who did not have any occupation (AOR=3.409, 95% CI: 1.120 to 10.374) and presence of comorbid conditions (AOR=2.004, 95% CI: 1.095 to 3.668) were predictors of DRH.
Nearly 90% of DRH was deemed to be preventable in the study settings. Older age, lower educational level, unemployment and presence of comorbid conditions in hospital as an inpatient were predictors of DRH.
本研究旨在确定埃塞俄比亚亚的斯亚贝巴市医院急诊科就诊患者中与药物相关的住院治疗（DRH）的患病率、类别和预测因素。
通过患者访谈和病历回顾进行多中心前瞻性观察研究。
研究在埃塞俄比亚亚的斯亚贝巴的三家三级保健医院进行。
符合纳入标准的共有 423 名患者被纳入研究。
DRH 的患病率和可预防率、导致 DRH 的药物相关问题类别、涉及的药物和疾病以及与 DRH 显著相关的因素。
超过一半的患者（216 名，51.1%）为女性。平均年龄（标准差）为 47.50（±17.21）岁。平均住院时间（标准差）为 10.29（±8.99）天。近 60%（249 名）的患者因药物相关问题住院，其中 87.8%是可以预防的。超过一半（130 名，53%）的住院原因是未能接受药物治疗，37.85（94 名）名患者被归类为未治疗的指征。年龄≥65 岁（调整后的优势比（AOR）=7.451，95%置信区间：1.889 至 29.397）、高等教育水平（AOR=0.360，95%置信区间：0.141 至 0.923）、无任何职业的参与者（AOR=3.409，95%置信区间：1.120 至 10.374）和合并症的存在（AOR=2.004，95%置信区间：1.095 至 3.668）是 DRH 的预测因素。
在研究环境中，近 90%的 DRH 被认为是可以预防的。年龄较大、教育程度较低、失业以及作为住院患者存在合并症是 DRH 的预测因素。
