Suppr超能文献

在挪威初级保健中预防 2 型糖尿病、超重和肥胖:一项具有 60 个月随访结果的纵向设计和一项比较辍学者与完成者的横断面设计。

Preventing type 2 diabetes, overweight and obesity in the Norwegian primary healthcare: a longitudinal design with 60 months follow-up results and a cross-sectional design with comparison of dropouts versus completers.

机构信息

Centre for Obesity Research (ObeCe), Department of Surgery, St. Olavs University Hospital, Trondheim, Norway

Faculty of Education and Arts, Nord Universitet-Levanger Campus, Levanger, Norway.

出版信息

BMJ Open. 2022 Mar 9;12(3):e054841. doi: 10.1136/bmjopen-2021-054841.

Abstract

OBJECTIVES

Studies have demonstrated that it is possible to prevent type 2 diabetes for individuals at high risk, but long-term results in the primary healthcare are limited and high dropout rates have been reported.

DESIGN

A longitudinal design was used to study changes in participants' diabetes risk and anthropometrics from baseline to 60 months follow-up. A cross-sectional design was applied to investigate differences between dropouts and completers of the 60 months follow-up.

SETTING

Healthy Life Centres in the Norwegian primary healthcare.

PARTICIPANTS

189 individuals aged >18 years with a Finnish Diabetes Risk Score ≥12 and/or a body mass index (BMI) ≥25 kg/m were included and offered to attend Healthy Life Centre programmes for 12 months. Measurements were performed annually up to 60 months after inclusion.

INTERVENTIONS

Healthy Life Centres arrange behavioural programmes including physical activity offers and dietary courses as part of the primary healthcare. This study offered individuals to attend Healthy Life Centre programmes and followed them for 60 months.

PRIMARY OUTCOME

Assess changes in participants' diabetes risk, cardiovascular measures and anthropometrics from baseline to 60 months.

SECONDARY OUTCOME

Investigate characteristics of dropouts compared with completers of 60 months follow-up.

RESULTS

For participants at 60 months follow-up, diabetes risk and anthropometrics decreased (p<0.001). Out of 65 participants classified as high risk for diabetes at baseline, 27 (42%) changed to being at moderate risk at 60 months follow-up. Remission of diabetes was seen for six of nine participants. Of 189 participants enrolled in the programme, 54 (31%) dropped out at any given point before 60 months follow-up. Dropouts were younger with higher, BMI, weight and waist circumference compared with the completers (p<0.001).

CONCLUSIONS

Having a long-term commitment for participants in primary healthcare interventions could be beneficial for the reduction of diabetes risk and improvement of anthropometrics as shown at the 60 months follow-up.

TRIAL REGISTRATION NUMBER

NCT01135901.

摘要

目的

研究表明,对高危人群进行 2 型糖尿病预防是可行的,但初级保健中的长期结果有限,且报道称脱落率较高。

设计

采用纵向设计研究参与者的糖尿病风险和人体测量学指标从基线到 60 个月随访的变化。应用横断面设计调查 60 个月随访脱落者和完成者之间的差异。

地点

挪威初级保健中的健康生活中心。

参与者

纳入年龄>18 岁、芬兰糖尿病风险评分≥12 和/或体重指数(BMI)≥25kg/m2的 189 名个体,并邀请他们参加为期 12 个月的健康生活中心项目。纳入后每年进行测量,直至 60 个月。

干预措施

健康生活中心安排行为项目,包括体育活动和饮食课程,作为初级保健的一部分。本研究邀请个体参加健康生活中心项目,并对其进行 60 个月随访。

主要结局

评估参与者从基线到 60 个月的糖尿病风险、心血管指标和人体测量学的变化。

次要结局

调查与 60 个月随访完成者相比,脱落者的特征。

结果

对于 60 个月随访的参与者,糖尿病风险和人体测量学指标下降(p<0.001)。在基线时被归类为糖尿病高危的 65 名参与者中,27 名(42%)在 60 个月随访时转为中度风险。9 名参与者中有 6 名糖尿病缓解。在纳入该计划的 189 名参与者中,54 名(31%)在 60 个月随访前的任何时间点脱落。与完成者相比,脱落者更年轻,BMI、体重和腰围更高(p<0.001)。

结论

初级保健干预中让参与者长期参与可能有益于降低糖尿病风险和改善人体测量学,这在 60 个月随访中得到了体现。

试验注册号

NCT01135901。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0ffb/8915299/52527f5b97a2/bmjopen-2021-054841f01.jpg

文献检索

告别复杂PubMed语法,用中文像聊天一样搜索,搜遍4000万医学文献。AI智能推荐,让科研检索更轻松。

立即免费搜索

文件翻译

保留排版,准确专业,支持PDF/Word/PPT等文件格式,支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述,25分钟生成高质量综述,智能提取关键信息,辅助科研写作。

立即免费体验