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SARS-CoV-2 spike L452R mutation increases Omicron variant fusogenicity and infectivity as well as host glycolysis.

作者信息

Zhang Yanan, Zhang Ting, Fang Yihui, Liu Jie, Ye Qinong, Ding Lihua

机构信息

Department of Medical Molecular Biology, Beijing Institute of Biotechnology, Beijing, 100850, P. R. China.

Faculty of Environment and Life, Beijing University of Technology, Beijing, 100124, P. R. China.

出版信息

Signal Transduct Target Ther. 2022 Mar 9;7(1):76. doi: 10.1038/s41392-022-00941-z.

DOI:10.1038/s41392-022-00941-z
PMID:35264568
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8905570/
Abstract
摘要
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0ad6/8907318/4c250cc96f83/41392_2022_941_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0ad6/8907318/4c250cc96f83/41392_2022_941_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0ad6/8907318/4c250cc96f83/41392_2022_941_Fig1_HTML.jpg

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SARS-CoV-2 spike L452R mutation increases Omicron variant fusogenicity and infectivity as well as host glycolysis.

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[5]
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[6]
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[7]
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[8]
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[9]
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[10]
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[2]
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[3]
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[4]
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[5]
evaluation of and extract activity against SARS-CoV-2 Delta variant in Golden Syrian hamsters: Potential herbal alternative for COVID-19 treatment.

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[6]
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[7]
Features of Highly Homologous T-Cell Receptor Repertoire in the Immune Response to Mutations in Immunogenic Epitopes.

Int J Mol Sci. 2024-11-23

[8]
Ongoing evolution of SARS-CoV-2 drives escape from mRNA vaccine-induced humoral immunity.

Cell Rep Med. 2024-12-17

[9]
Utilizing Feline Lentiviral Infection to Establish a Translational Model for COVID-19 in People with Human Immunodeficiency Virus Infection.

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[10]
Temperature-dependent Spike-ACE2 interaction of Omicron subvariants is associated with viral transmission.

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本文引用的文献

[1]
Structural and functional characterizations of infectivity and immune evasion of SARS-CoV-2 Omicron.

Cell. 2022-3-3

[2]
Characteristics and Outcomes of Hospitalized Patients in South Africa During the COVID-19 Omicron Wave Compared With Previous Waves.

JAMA. 2022-2-8

[3]
The Mechanism and Consequences of SARS-CoV-2 Spike-Mediated Fusion and Syncytia Formation.

J Mol Biol. 2022-3-30

[4]
SARS-CoV-2 spike L452R variant evades cellular immunity and increases infectivity.

Cell Host Microbe. 2021-7-14

[5]
Loss of furin cleavage site attenuates SARS-CoV-2 pathogenesis.

Nature. 2021-3

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