Suzumura Hirotaka, Yoshikawa Keiji, Kimura Tairo, Nanno Mami, Tsumura Toyoaki
Suzumura Eye Clinic, Tokyo, Japan.
Yoshikawa Eye Clinic, Tokyo, Japan.
Clin Ophthalmol. 2022 Mar 3;16:611-618. doi: 10.2147/OPTH.S354381. eCollection 2022.
To develop a cluster system to analyze the retinal sensitivity loss of 68 test points in the central 10 degrees of standard automated perimetry (SAP) in eyes with normal tension glaucoma (NTG).
Patients with NTG who met the following criteria were included: visual acuity ≥0.7, SAP-derived mean deviation ≥-15 dB, and pattern deviation probability plots with at least one point with a probability of <0.5% and/or two or more contiguous points with a probability of <1% that did not cross the horizontal meridian in the central 12 points of the 24-2 test points. SAP with the Swedish Interactive Threshold Algorithm Standard (SITA-S) 10-2 program (10-2) was performed within 6 months of the SITA-S 24-2. The averaged total deviation (TD) for each of the 68 test points in the 10-2 was calculated. Hierarchical cluster analyses were performed based on the deviation of the TDs of the test points, and a dendrogram was created. The number of clusters was determined following the Sturges' rule.
One hundred and twenty-six eyes of 126 patients (61.9±11.4 years) were studied. Hierarchical cluster analysis of the TD values statistically obtained a dendrogram that divided the 68 test points into 7 clusters. Of these 7 clusters, 21 points belonging to the clusters in the papillomacular region included cluster 5. Cluster 5 was distributed above and below the horizontal meridian, which does not agree with the course of the retinal nerve fiber layer (RNFL).
The hierarchical cluster analysis of the TD values stratified the 68 test points of the 10-2 into seven clusters. Considering the course of the RNFL, cluster 5 was divided into clusters of 5a and 5b, and consequently eight clusters were considered to be appropriate for detecting glaucomatous visual field defects in the central 10 degrees in NTG eyes.
开发一种聚类系统，以分析正常眼压性青光眼（NTG）患者标准自动视野计（SAP）中央10度范围内68个测试点的视网膜敏感度丧失情况。
纳入符合以下标准的NTG患者：视力≥0.7，SAP得出的平均偏差≥ -15 dB，以及在24-2测试点的中央12个点中，模式偏差概率图至少有一个点的概率<0.5%和/或两个或更多连续点的概率<1%且未穿过水平子午线。在SITA-S 24-2检查的6个月内进行瑞典交互式阈值算法标准（SITA-S）10-2程序（10-2）的SAP检查。计算10-2中68个测试点各自的平均总偏差（TD）。基于测试点TD的偏差进行层次聚类分析，并创建树状图。根据斯特奇斯法则确定聚类数量。
研究了126例患者的126只眼（年龄61.9±11.4岁）。对TD值进行层次聚类分析，从统计学上获得了一个将68个测试点分为7个聚类的树状图。在这7个聚类中，属于黄斑乳头区聚类的21个点包括聚类5。聚类5分布在水平子午线的上方和下方，这与视网膜神经纤维层（RNFL）的走行不一致。
对TD值进行层次聚类分析将10-2的68个测试点分层为7个聚类。考虑到RNFL的走行，将聚类5分为5a和5b聚类，因此认为8个聚类适合检测NTG患者中央10度范围内的青光眼性视野缺损。
