Sugihara Kae, Kong Yu Xiang George, Hosokawa Mitsuto, Okanouchi Toshio
Department of Ophthalmology, Kurashiki Medical Center, Kurashiki, Okayama, Japan.
Royal Victorian Eye and Ear Hospital, East Melbourne, Australia.
Transl Vis Sci Technol. 2025 Sep 2;14(9):14. doi: 10.1167/tvst.14.9.14.
Melbourne rapid fields (MRF) online perimetry is web-based software that allows white-on-white threshold perimetry using any computer. This study assesses the perimetric outcomes of MRF10-2 protocol via laptop computer in comparison to Humphrey field analyzer (HFA).
This prospective and cross-sectional study included 91 eyes from 91 Japanese glaucoma patients. MRF10-2 visual field (VF) results were compared to HFA10-2 the Swedish Interactive Thresholding Algorithm (SITA)-Standard, including mean deviation (MD), pattern deviation (PD), and reliability indexes. To assess test-retest reliability, patients completed two MRF assessments.
MRF demonstrated high level of agreement with HFA in evaluating MD (intraclass correlation coefficient [ICC] = 0.97 [95% confidence interval {CI}, 0.96-0.98]) and pattern standard deviation (PSD; ICC = 0.94 [95% CI, 0.92-0.96]). Bland-Altman analysis revealed a mean bias of -1.31 decibels (dB) (95% limits of agreement [LoA] = -7.21 dB, 4.59 dB) for MD and 0.71 dB (LoA = -3.55 dB, 4.97 dB) for PSD. It also demonstrated good MRF repeatability with a mean bias of 0.39 dB (LoA = -2.34 dB, 3.00 dB) for MD and -0.21 dB (LoA = -2.36 dB, 1.94 dB) for PSD. False-positives and -negatives were not statistically different between the two devices. MRF test time was significantly shorter than HFA (P < 0.001).
MRF10-2 online perimetry offers portable approach for central VF assessment, but its measurements are not directly interchangeable with HFA and may exhibit higher variability, warranting caution in clinical interpretation.
The novel protocol of portable online perimetry approach will assess central VF defects when standard equipment is unavailable.
墨尔本快速视野（MRF）在线视野检查法是一种基于网络的软件，可使用任何计算机进行白对白阈值视野检查。本研究通过笔记本电脑评估MRF10 - 2协议的视野检查结果，并与 Humphrey 视野分析仪（HFA）进行比较。
这项前瞻性横断面研究纳入了91例日本青光眼患者的91只眼睛。将MRF10 - 2视野（VF）结果与HFA10 - 2瑞典交互式阈值算法（SITA）-标准进行比较，包括平均偏差（MD）、模式偏差（PD）和可靠性指标。为评估重测信度，患者完成了两次MRF评估。
MRF在评估MD（组内相关系数[ICC]=0.97[95%置信区间{CI}，0.96 - 0.98]）和模式标准差（PSD；ICC = 0.94[95% CI，0.92 - 0.96]）方面与HFA显示出高度一致性。Bland - Altman分析显示，MD的平均偏差为 - 1.31分贝（dB）（95%一致性界限[LoA]= - 7.21 dB，4.59 dB），PSD的平均偏差为0.71 dB（LoA = - 3.55 dB，4.97 dB）。它还显示出良好的MRF重复性，MD的平均偏差为0.39 dB（LoA = - 2.34 dB，3.00 dB），PSD的平均偏差为 - 0.21 dB（LoA = - 2.36 dB，1.94 dB）。两种设备之间的假阳性和假阴性在统计学上无差异。MRF检查时间明显短于HFA（P < 0.001）。
MRF10 - 2在线视野检查法为中心VF评估提供了一种便携式方法，但其测量结果不能直接与HFA互换，且可能表现出更高的变异性，在临床解读时需谨慎。
便携式在线视野检查法的新协议将在没有标准设备时评估中心VF缺陷。
