Department of Emergency Medicine, The First Affiliated Hospital of Soochow University, Suzhou 215006, China.
Trauma Center, The First Affiliated Hospital of Soochow University, Suzhou 215006, China.
Pain Res Manag. 2022 Feb 27;2022:3489160. doi: 10.1155/2022/3489160. eCollection 2022.
The present study investigated the clinical efficacy of percutaneous kyphoplasty (PKP) combined with calcitriol and calcium in the treatment of traumatic nonosteoporotic vertebral compression fractures (TNVCFs).
The patients were equally divided into a control group and a treatment group by a random number table. The patients in the control group underwent PKP surgery, and the patients in the treatment group received calcitriol and calcium on the basis of PKP surgery. The visual analog scale (VAS) pain scores, Oswestry Disability Index (ODI) scores, the height of the anterior edge of the vertebral body, Cobb's angle, and the level of the bone mineral density of the two groups of TNVCF patients before surgery were recorded and compared, one and six months after surgery.
Thirty-six inpatients with TNVCFs admitted to the trauma center of the First Affiliated Hospital of Soochow University from January 2019 to January 2020 were recruited. There were no significant differences in the VAS and ODI scores, the height of the anterior edge of the injured vertebral body, Cobb's angle, and bone mineral density between the two groups before surgery ( > 0.05). The VAS scores, ODI scores, the height of the anterior edge of the injured vertebral body, and Cobb's angle of the two groups of patients after surgery were significantly better than those before surgery. One and six months after surgery, the VAS and ODI scores, the height of the anterior edge of the injured vertebral body, Cobb's angle, and the bone mineral density of the patients in the treatment group improved significantly compared to those in the control group ( < 0.05).
PKP combined with calcitriol and calcium medications could significantly relieve pain, alleviate the loss of compressed vertebral height and kyphosis, and improve the spinal function and the life quality of the TNVCF patients.
本研究旨在探讨经皮椎体后凸成形术（PKP）联合骨化三醇和钙剂治疗创伤性非骨质疏松性椎体压缩骨折（TNVCF）的临床疗效。
采用随机数字表法将 2019 年 1 月至 2020 年 1 月苏州大学附属第一医院创伤中心收治的 36 例 TNVCF 患者等分为对照组和观察组。对照组患者行 PKP 手术，观察组患者在 PKP 手术基础上联合骨化三醇和钙剂治疗。记录并比较两组患者术前及术后 1、6 个月的视觉模拟评分（VAS）疼痛评分、Oswestry 功能障碍指数（ODI）评分、伤椎前缘高度、Cobb 角及骨密度水平。
36 例 TNVCF 患者纳入研究，两组患者术前 VAS 及 ODI 评分、伤椎前缘高度、Cobb 角及骨密度比较，差异均无统计学意义（>0.05）。两组患者术后 VAS 及 ODI 评分、伤椎前缘高度、Cobb 角均明显优于术前，且观察组术后 1、6 个月 VAS 及 ODI 评分、伤椎前缘高度、Cobb 角及骨密度改善情况均明显优于对照组（均<0.05）。
PKP 联合骨化三醇和钙剂治疗可明显缓解 TNVCF 患者疼痛，减少伤椎高度丢失及后凸畸形，改善脊柱功能，提高患者生活质量。
