Du Weiliang, Li Wenshuai, Kang Lixing, Wang Linfeng
Weiliang Du Department of Orthopedics, Langfang People's Hospital, 37 Xinhua Road, Langfang, Hebei Province 065000, P.R. China.
Wenshuai Li, The Third Hospital of Hebei Medical University, 139 Ziqiang Road, Shijiazhuang, Hebei Province 065000, P.R. China.
Pak J Med Sci. 2025 Apr;41(4):1013-1018. doi: 10.12669/pjms.41.4.11569.
To explore the effectiveness of percutaneous kyphoplasty (PKP) combined with different anti-osteoporosis drugs in the treatment of osteoporotic vertebral compression fractures (OVCF) by assessing bone mineral density, pain, lumbar functional recovery, and incidence of vertebral refractures after the combined therapy.
In this single-center retrospective study, medical records of 138 patients with OVCF who underwent PKP in the Third Hospital of Hebei Medical University between January 2021 and October 2022 were retrospectively analyzed. Among them, 41 patients treated with calcium and alfacalciferol supplementation after PKP (Group-A), 58 patients treated with calcium and calcitonin after PKP (Group-B), and 39 patients treated with calcium, calcitonin, and alendronate sodium after PKP (Group-C). Bone mineral density, pain, lumbar functional recovery, and incidence of vertebral refractures in the three groups were compared before and after PKP.
At six and 12 months after PKP, bone density T-values of Group-B and Group-C were significantly higher than Group-A (P<0.05). The visual analogue scale (VAS) scores of Group-B and Group-C were significantly lower than Group-A (<0.05). At 12 months after PKP, T-value of bone density in Group-C was significantly higher, while the VAS score was significantly lower than Group-B; At six months after PKP, the Cobb angle in Group-B and Group-C was significantly lower than Group-A (<0.05). At 12 months after PKP, Oswestry disability index (ODI) and Cobb angle of Group-B and Group-C were significantly lower than Group-A, and the lowest in Group-C. The extent of vertebral loss in Group-C was significantly lower than Groups A and B (<0.05).
In the treatment of osteoporotic vertebral compression fractures after percutaneous kyphoplasty, a combination of calcium therapy with calcitonin and alendronate sodium had a positive effect, which may effectively improve bone density, pain, and functional status, and reduce the incidence of vertebral body fractures.
通过评估经皮椎体后凸成形术（PKP）联合不同抗骨质疏松药物治疗骨质疏松性椎体压缩骨折（OVCF）后的骨密度、疼痛情况、腰椎功能恢复情况及椎体再骨折发生率，探讨其治疗效果。
在这项单中心回顾性研究中，对2021年1月至2022年10月期间在河北医科大学第三医院接受PKP治疗的138例OVCF患者的病历进行回顾性分析。其中，41例患者PKP术后接受钙剂及阿法骨化醇补充治疗（A组），58例患者PKP术后接受钙剂及降钙素治疗（B组），39例患者PKP术后接受钙剂、降钙素及阿仑膦酸钠治疗（C组）。比较三组患者PKP术前及术后的骨密度、疼痛情况、腰椎功能恢复情况及椎体再骨折发生率。
PKP术后6个月和12个月时，B组和C组的骨密度T值显著高于A组（P<0.05）。B组和C组的视觉模拟评分（VAS）显著低于A组（<0.05）。PKP术后12个月时，C组的骨密度T值显著更高，而VAS评分显著低于B组；PKP术后6个月时，B组和C组的Cobb角显著低于A组（<0.05）。PKP术后12个月时，B组和C组的Oswestry功能障碍指数（ODI）及Cobb角显著低于A组，且C组最低。C组椎体丢失程度显著低于A组和B组（<0.05）。
在经皮椎体后凸成形术治疗骨质疏松性椎体压缩骨折中，钙剂联合降钙素及阿仑膦酸钠治疗具有积极作用，可有效提高骨密度、缓解疼痛、改善功能状态，并降低椎体骨折发生率。
