嵌合抗原受体（CAR）T细胞在实体瘤中的分散播种可增强抗癌疗效。
Scattered seeding of CAR T cells in solid tumors augments anticancer efficacy.
作者信息
Li Hongjun, Wang Zejun, Ogunnaike Edikan A, Wu Qing, Chen Guojun, Hu Quanyin, Ci Tianyuan, Chen Zhaowei, Wang Jinqiang, Wen Di, Du Hongwei, Jiang Jie, Sun Jie, Zhang Xingcai, Dotti Gianpietro, Gu Zhen
机构信息
College of Pharmaceutical Sciences, Zhejiang University, Hangzhou 310058, China.
Department of Bioengineering, University of California, Los Angeles, CA 90095, USA.
出版信息
Natl Sci Rev. 2021 Sep 21;9(3):nwab172. doi: 10.1093/nsr/nwab172. eCollection 2022 Mar.
Chimeric antigen receptor T cell (CAR T) therapy was a milestone in the treatment of relapsed and refractory B cell malignancies. However, beneficial effects of CAR T cells have not been obtained in solid tumors yet. Herein, we implement a porous microneedle patch that accommodates CAR T cells and allows penetration-mediated seeding of CAR T cells when implanted in the tumor bed or in the post-surgical resection cavity. CAR T cells loaded in the pores of the microneedle tips were readily escorted to the tumor in an evenly scattered manner without losing their activity. Such microneedle-mediated local delivery enhanced infiltration and immunostimulation of CAR T cells as compared to direct intratumoral injection. This tailorable patch offers a transformative platform for scattered seeding of living cells for treating a variety of tumors.
嵌合抗原受体T细胞（CAR T）疗法是复发难治性B细胞恶性肿瘤治疗的一个里程碑。然而，CAR T细胞在实体瘤中尚未取得有益效果。在此，我们制作了一种多孔微针贴片，其可容纳CAR T细胞，并在植入肿瘤床或手术切除腔时实现CAR T细胞的穿透介导播种。加载在微针尖端孔隙中的CAR T细胞能够以均匀分散的方式轻松地被输送到肿瘤部位，且不会丧失活性。与直接瘤内注射相比，这种微针介导的局部递送增强了CAR T细胞的浸润和免疫刺激作用。这种可定制的贴片为活细胞的分散播种提供了一个变革性平台，用于治疗多种肿瘤。
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