Lv Xing, Zhang Mingzhu, Xu Wen
College of Medical Science, China Three Gorges University, Yichang, 443002, China.
Mini Rev Med Chem. 2023;23(22):2090-2096. doi: 10.2174/1389557523666230313144742.
LncRNA not only plays an auxiliary role as an intermediate carrier of genetic information, but also mediates various regulatory functions. The complex and precise regulatory function of lncRNA in development and gene expression has greatly explained the complexity of the genome, and also opened a new avenue for people to understand the complexity of life from the dimension of gene expression. Long non-coding RNA (lncRNA) prostate cancer gene expression marker 1 (PCGEM1) is a characterized oncogenic lncRNA in different cancers. This review is dedicated to summarizing the various molecular mechanisms of PCGEM1 and demonstrates that the biological functions exerted by PCGEM1 are good starting points for therapy.
The molecular mechanism of PCGEM1 acting on tumors has been summarized by reviewing the literature available on PubMed.
The expression of lncRNA PCGEM1 is abnormally increased in all kinds of tumors, including cervical cancer, prostate cancer, renal carcinoma, gastric cancer, lung cancer, ovarian carcinoma, cough variant asthma, and castration tolerant prostate cancer. Besides, PCGEM1 mediates multiple processes involved in carcinogenesis, including proliferation, invasion, anti-apoptosis, and migration.
The potential of PCGEM1 as a therapeutic target for cancer is revealed.
长链非编码RNA（lncRNA）不仅作为遗传信息的中间载体发挥辅助作用，还介导多种调控功能。lncRNA在发育和基因表达中复杂而精确的调控功能极大地解释了基因组的复杂性，也为人们从基因表达维度理解生命的复杂性开辟了新途径。长链非编码RNA（lncRNA）前列腺癌基因表达标志物1（PCGEM1）是不同癌症中一种具有特征性的致癌lncRNA。本综述致力于总结PCGEM1的各种分子机制，并证明PCGEM1发挥的生物学功能是治疗的良好切入点。
通过回顾PubMed上的可用文献，总结了PCGEM1作用于肿瘤的分子机制。
lncRNA PCGEM1在包括宫颈癌、前列腺癌、肾癌、胃癌、肺癌、卵巢癌、咳嗽变异性哮喘和去势抵抗性前列腺癌在内的各种肿瘤中表达异常增加。此外，PCGEM1介导参与致癌作用的多个过程，包括增殖、侵袭、抗凋亡和迁移。
揭示了PCGEM1作为癌症治疗靶点的潜力。
