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基于医疗保健双聚类的基因表达数据集预测。

Healthcare Biclustering-Based Prediction on Gene Expression Dataset.

机构信息

Department of Computer Science and Engineering, HKBK College of Engineering, India.

Department of Computer Science and Engineering, Sona College of Technology, India.

出版信息

Biomed Res Int. 2022 Feb 22;2022:2263194. doi: 10.1155/2022/2263194. eCollection 2022.

Abstract

In this paper, we develop a healthcare biclustering model in the field of healthcare to reduce the inconveniences linked to the data clustering on gene expression. The present study uses two separate healthcare biclustering approaches to identify specific gene activity in certain environments and remove the duplication of broad gene information components. Moreover, because of its adequacy in the problem where populations of potential solutions allow exploration of a greater portion of the research area, machine learning or heuristic algorithm has become extensively used for healthcare biclustering in the field of healthcare. The study is evaluated in terms of average match score for nonoverlapping modules, overlapping modules through the influence of noise for constant bicluster and additive bicluster, and the run time. The results show that proposed FCM blustering method has higher average match score, and reduced run time proposed FCM than the existing PSO-SA and fuzzy logic healthcare biclustering methods.

摘要

在本文中,我们开发了一种医疗保健中的双聚类模型,以减少与基因表达数据聚类相关的不便。本研究使用两种独立的医疗保健双聚类方法来识别特定环境中的特定基因活性,并去除广泛基因信息组件的重复。此外,由于其在潜在解决方案群体允许探索更大部分研究区域的问题中的适当性,机器学习或启发式算法已广泛用于医疗保健中的医疗保健双聚类。该研究从非重叠模块的平均匹配分数、恒定双聚类和加性双聚类的噪声影响的重叠模块以及运行时间等方面进行了评估。结果表明,所提出的 FCM 聚类方法比现有的 PSO-SA 和模糊逻辑医疗保健双聚类方法具有更高的平均匹配分数和更低的运行时间。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d13c/8901349/7a1f78dc49c7/BMRI2022-2263194.001.jpg

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