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扁平苔藓样天疱疮:一种继发于纳武利尤单抗的独特的水疱性和苔藓样发疹形式。

Lichen planus pemphigoides: A unique form of bullous and lichenoid eruptions secondary to nivolumab.

机构信息

Department of Dermatology, Rutgers New Jersey Medical School, Newark, New Jersey, USA.

Department of Dermatology, ProPath, Dallas, Texas, USA.

出版信息

Dermatol Ther. 2022 May;35(5):e15432. doi: 10.1111/dth.15432. Epub 2022 Mar 15.

Abstract

The widespread use of PD-1 inhibitors to treat various solid tumors has brought certain challenges for the clinician, including immune-related adverse events (irAEs). Cutaneous toxicities are among the most observed irAEs. Bullous and lichenoid dermatoses following PD-1 inhibitor therapy have been described. Here we report a novel case of lichen planus pemphigoides, featuring characteristics of both bullous pemphigoid and lichen planus, in a patient treated with nivolumab for renal cell carcinoma. We subsequently review all three cutaneous conditions which may arise in the context of PD-1 inhibitor therapy.

摘要

PD-1 抑制剂被广泛用于治疗各种实体瘤,这给临床医生带来了一定的挑战,包括免疫相关不良事件(irAEs)。皮肤毒性是最常见的 irAEs 之一。已有报道称 PD-1 抑制剂治疗后会出现大疱性和苔藓样皮肤病。在此,我们报告了一例新型扁平苔藓大疱性类天疱疮,其特征同时具有大疱性类天疱疮和扁平苔藓的特点,发生于接受纳武利尤单抗治疗肾细胞癌的患者。随后,我们对 PD-1 抑制剂治疗相关的三种可能出现的皮肤疾病进行了综述。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/615d/9286841/a8b9d07426f4/DTH-35-0-g006.jpg

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