Department of Dermatology, Rutgers New Jersey Medical School, Newark, New Jersey, USA.
Department of Dermatology, ProPath, Dallas, Texas, USA.
Dermatol Ther. 2022 May;35(5):e15432. doi: 10.1111/dth.15432. Epub 2022 Mar 15.
The widespread use of PD-1 inhibitors to treat various solid tumors has brought certain challenges for the clinician, including immune-related adverse events (irAEs). Cutaneous toxicities are among the most observed irAEs. Bullous and lichenoid dermatoses following PD-1 inhibitor therapy have been described. Here we report a novel case of lichen planus pemphigoides, featuring characteristics of both bullous pemphigoid and lichen planus, in a patient treated with nivolumab for renal cell carcinoma. We subsequently review all three cutaneous conditions which may arise in the context of PD-1 inhibitor therapy.
PD-1 抑制剂被广泛用于治疗各种实体瘤,这给临床医生带来了一定的挑战,包括免疫相关不良事件(irAEs)。皮肤毒性是最常见的 irAEs 之一。已有报道称 PD-1 抑制剂治疗后会出现大疱性和苔藓样皮肤病。在此,我们报告了一例新型扁平苔藓大疱性类天疱疮,其特征同时具有大疱性类天疱疮和扁平苔藓的特点,发生于接受纳武利尤单抗治疗肾细胞癌的患者。随后,我们对 PD-1 抑制剂治疗相关的三种可能出现的皮肤疾病进行了综述。