轻度镇静剂与道路交通事故
Minor tranquillisers and road accidents.
作者信息
Skegg D C, Richards S M, Doll R
出版信息
Br Med J. 1979 Apr 7;1(6168):917-9. doi: 10.1136/bmj.1.6168.917.
Abstract
In a prospective study of 43,117 people, prescriptions issued by general practitioners over two years were linked with records of hospital admissions and deaths. For 57 people injured or killed while driving cars, motorcycles, or bicycles the medicines that had been dispensed in the three months before were compared with those dispensed for 1,425 matched controls. There was a highly significant association between use of minor tranquillisers and the risk of a serious road accident (relative risk estimate 4.9). the increased risk of accidents to drivers given tranquillisers could be due to the known psychomotor effects of these drugs or to effects of the conditions being treated. Whatever the reason, patients taking drugs such as diazepam should be warned that they are at special risk.
摘要
在一项针对43117人的前瞻性研究中，全科医生在两年内开出的处方与住院和死亡记录相关联。对于57名在驾驶汽车、摩托车或自行车时受伤或死亡的人，将他们在事故前三个月所配发的药物与1425名匹配对照者所配发的药物进行了比较。使用小剂量镇静剂与严重道路事故风险之间存在高度显著的关联（相对风险估计值为4.9）。给司机服用镇静剂后事故风险增加可能是由于这些药物已知的精神运动效应，或者是由于所治疗病症的影响。无论原因是什么，都应该警告服用地西泮等药物的患者，他们面临特殊风险。
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