Betts T A, Clayton A B, Mackay G M
Br Med J. 1972 Dec 9;4(5840):580-4. doi: 10.1136/bmj.4.5840.580.
A double-blind controlled comparison of four commonly-used tranquillizing drugs (haloperidol, amylobarbitone sodium, chlordiazepoxide, and trifluoperazine) against placebo was made in their effects on the performance of volunteers during three low speed vehicle-handling tests. The drugs (with the exception of haloperidol) significantly altered driving behaviour though they did not seem to interact significantly with alcohol. There is, therefore, a strong possibility that such drugs will similarly alter driving performance in patients taking them for therapeutic purposes. Since, as these experiments also show, those affected may be subjectively unaware of it, and routine clinical screening is not sensitive enough to detect them, physicians should warn patients of the probability that their driving performance will be affected by such drugs, particularly during the first few days that they are taken.
对四种常用镇静药物（氟哌啶醇、戊巴比妥钠、氯氮卓和三氟拉嗪）与安慰剂进行了双盲对照比较，观察它们在三项低速车辆操控测试中对志愿者表现的影响。这些药物（氟哌啶醇除外）显著改变了驾驶行为，尽管它们似乎与酒精没有显著相互作用。因此，服用这些药物用于治疗目的的患者，其驾驶性能很可能同样会受到影响。由于这些实验还表明，受影响者可能主观上并未意识到这一点，而且常规临床筛查不够灵敏，无法检测到这些影响，医生应警告患者，此类药物可能会影响其驾驶性能，尤其是在服药的头几天。
