体外测定络合锌和硒的腐殖物质对新型冠状病毒复制的抑制作用
In Vitro Determination of Inhibitory Effects of Humic Substances Complexing Zn and Se on SARS-CoV-2 Virus Replication.
作者信息
Hajdrik Polett, Pályi Bernadett, Kis Zoltán, Kovács Noémi, Veres Dániel Sándor, Szigeti Krisztián, Budán Ferenc, Hegedüs Imre, Kovács Tibor, Bergmann Ralf, Máthé Domokos
机构信息
Department of Biophysics and Radiation Biology, Semmelweis University, Üllői út 26., H-1085 Budapest, Hungary.
National Biosafety Laboratory, National Public Health Center, Albert Flórián út 2-6, H-1097 Budapest, Hungary.
出版信息
Foods. 2022 Feb 26;11(5):694. doi: 10.3390/foods11050694.
(1) Background: Humic substances are well-known human nutritional supplement materials and they play an important performance-enhancing role as animal feed additives. For decades, ingredients of humic substances have been proven to carry potent antiviral effects against different viruses. (2) Methods: Here, the antiviral activity of a humic substance containing ascorbic acid, Se and Zn ions intended as a nutritional supplement material was investigated against SARS-CoV-2 virus B1.1.7 Variant of Concern ("Alpha Variant") in a VeroE6 cell line. (3) Results: This combination has a significant in vitro antiviral effect at a very low concentration range of its intended active ingredients. (4) Conclusions: Even picomolar concentration ranges of humic substances, Vitamin C and Zn/Se ions in the given composition, were enough to achieve 50% viral replication inhibition in the applied SARS-CoV-2 virus inhibition test.
(1) 背景：腐殖质是众所周知的人类营养补充材料，并且作为动物饲料添加剂发挥着重要的性能增强作用。几十年来，腐殖质的成分已被证明对不同病毒具有强大的抗病毒作用。(2) 方法：在此，在VeroE6细胞系中研究了一种含有抗坏血酸、硒和锌离子的腐殖质作为营养补充材料对严重急性呼吸综合征冠状病毒2（SARS-CoV-2）病毒B.1.1.7变异株（“阿尔法变异株”）的抗病毒活性。(3) 结果：这种组合在其预期活性成分的极低浓度范围内具有显著的体外抗病毒作用。(4) 结论：在应用的SARS-CoV-2病毒抑制试验中，给定组合物中即使皮摩尔浓度范围的腐殖质、维生素C和锌/硒离子也足以实现50%的病毒复制抑制。
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