Sukumar Jasmine S, Vaughn Jennifer E, Tegge Allison, Sardesai Sagar, Lustberg Maryam, Stein Jeffrey
Division of Medical Oncology, The Ohio State University Comprehensive Cancer Center, Columbus, OH 43221, USA.
Stefanie Spielman Comprehensive Breast Center, The Ohio State University, Columbus, OH 43212, USA.
Cancers (Basel). 2022 Feb 23;14(5):1134. doi: 10.3390/cancers14051134.
Obesity in breast cancer (BC) survivors is associated with increased mortality. Delay discounting (DD) is a behavioral economic measure of how individuals value future outcomes. Higher DD correlates with obesity in the general population. Valuation of the future may be associated with obesity differently in cancer survivors. This study evaluated the relationship between DD and obesity in BC survivors. We report an exploratory analysis assessing cross-sectional associations between DD, BMI, and lifestyle behaviors (vegetable and fruit consumption, exercise) related to obesity in 89 women with hormone receptor positive non-metastatic BC. Multivariate linear regression analysis examined demographic and lifestyle behavior variables associated with both BMI and DD. Greater willingness to wait for larger, delayed rewards (lower DD) was significantly associated with lower BMI (standardized beta = −0.32; p < 0.01), independent of age, race, income, time since diagnosis, and menopausal status. There was no significant association between DD and fruit consumption or exercise frequency. Vegetable consumption was significantly associated with lower DD (standardized beta = 0.24; p < 0.05). Higher DD is associated with obesity and decreased frequency of vegetable consumption in BC survivors. Future studies should investigate DD as a therapeutic target for behavioral interventions to facilitate weight loss and promote longevity in this population.
乳腺癌（BC）幸存者肥胖与死亡率增加相关。延迟折扣（DD）是一种衡量个体如何评估未来结果的行为经济学指标。在一般人群中，较高的DD与肥胖相关。在癌症幸存者中，对未来的评估可能与肥胖存在不同的关联。本研究评估了BC幸存者中DD与肥胖之间的关系。我们报告了一项探索性分析，评估了89名激素受体阳性非转移性BC女性中DD、体重指数（BMI）以及与肥胖相关的生活方式行为（蔬菜和水果摄入量、运动情况）之间的横断面关联。多变量线性回归分析研究了与BMI和DD均相关的人口统计学和生活方式行为变量。更愿意等待更大的延迟奖励（较低的DD）与较低的BMI显著相关（标准化β=-0.32；p<0.01），不受年龄、种族、收入、确诊时间和绝经状态的影响。DD与水果摄入量或运动频率之间无显著关联。蔬菜摄入量与较低的DD显著相关（标准化β=0.24；p<0.05）。较高的DD与BC幸存者的肥胖以及蔬菜摄入量减少相关。未来的研究应将DD作为行为干预的治疗靶点进行调查，以促进该人群的体重减轻和延长寿命。
