Kasholm-Tengve B, Bartholdson P
Acta Chir Scand. 1986 Apr;152:267-72.
168 patients undergoing acute abdominal surgery for suspected peritoneal contamination were randomized consecutively to receive either a combination of ampicillin, mecillinam and metronidazole (group I) or cefoxitin (group II). Seventy-nine patients were evaluable in group I and 69 in group II. Postoperative surgical infections were seen in a total of 17 patients, 6 in group I (7.6%) and 11 in group II (15.9%). Evaluation of potential resistance development, side-effects and a trend towards better efficacy, together with a positive cost benefit analysis, have led us to adopt the combination of ampicillin, mecillinam and metronidazole as the standard treatment in cases of acute abdominal surgery. In the 18 months following the conclusion of the study, 263 patients undergoing acute abdominal surgery were treated with the triple combination. The infection rate in this material was 4.6%.
168例因疑似腹膜污染而接受急性腹部手术的患者被连续随机分组，分别接受氨苄西林、美西林和甲硝唑联合用药（第一组）或头孢西丁（第二组）治疗。第一组有79例患者可进行评估，第二组有69例。共有17例患者发生术后手术部位感染，第一组6例（7.6%），第二组11例（15.9%）。对潜在耐药性发展、副作用以及疗效更佳趋势的评估，再加上积极的成本效益分析，促使我们采用氨苄西林、美西林和甲硝唑联合用药作为急性腹部手术病例的标准治疗方法。在该研究结束后的18个月里，263例接受急性腹部手术的患者接受了三联用药治疗。该组患者的感染率为4.6%。
