Millan J, Bodian M, Naudin J C, Diouf B, Boucher P, Ndoye B, Grosset J
Acta Leprol. 1986 Jan-Mar;4(1):19-35.
Since 1982, in Dakar, a controlled essay tests the suitability of several short protocols of multidrug therapy (MDT), some of them being close to those advised by the WHO, others showing a starter stage of a two month daily MDT. In three years, 198 paucibacillary and 123 multibacillary patients have been treated. The short duration of these treatments leads to an important decrease in the load of the Department. The total rate of those who have not attended for the treatment is of 15.2% whereas it was of 52% with DDS monotherapy for a similar treatment duration. Those who gave up don't seem to live in Dakar. To judge by the diligence of the patients, the compliance seems excellent even for the protocols requiring a daily dose of ethionamide: 95% of paucibacillary, 76% of multibacillary patients have maximal attendance. The authors think that any MDT program: must be preceded by a retraining of staffs; must give a priority to the health education of the patients; must involve a home patient search for system.
自1982年起，在达喀尔，一项对照试验对几种短程联合化疗方案（MDT）的适用性进行了测试，其中一些方案与世界卫生组织建议的方案相近，另一些则呈现出为期两个月的每日MDT起始阶段。在三年时间里，共治疗了198例少菌型和123例多菌型患者。这些治疗疗程的缩短使得科室负担显著减轻。未接受治疗者的总比例为15.2%，而在类似治疗时长下，使用氨苯砜单药治疗时这一比例为52%。放弃治疗者似乎并非居住在达喀尔。从患者的勤勉程度判断，即使是对于需要每日服用乙硫异烟胺的方案，依从性似乎也极佳：95%的少菌型患者、76%的多菌型患者就诊情况良好。作者认为，任何MDT项目：必须先对工作人员进行再培训；必须优先开展患者健康教育；必须建立家庭患者搜寻系统。
