Department of Molecular Medicine, "Sapienza" University of Rome, 00161 Rome, Italy.
Department of Experimental Medicine, Section of Medical Physiopathology, Food Science and Endocrinology, "Sapienza" University of Rome, 00161 Rome, Italy.
Nutrients. 2022 Feb 25;14(5):983. doi: 10.3390/nu14050983.
Sirtuin1 (SIRT1) and sclerostin play important roles in adipose tissue and bone metabolism. We evaluated the circulating SIRT1 and sclerostin relationship with mass and quality of bone while considering the degree of adiposity. Sixty-six premenopausal women (16 underweight, 25 normal weight and 25 with obesity), aged <50 years, were enrolled. Plasma SIRT1, sclerostin and DXA body composition (total fat mass (FM), abdominal visceral adipose tissue, lean mass, trabecular bone score (TBS) and lumbar spine and femoral neck (FN) bone mineral density (BMD)) were assessed. The patients with obesity showed the lowest SIRT1 and TBS values and the highest sclerostin concentrations; BMD increased with FM and BMI and had an inverse association with SIRT1. Sclerostin was negatively correlated with SIRT1 (ρ = −0.37, p = 0.002). When spine BMD, FN BMD and TBS were standardized for BMI, a positive correlation with SIRT1 and a negative correlation with sclerostin were seen (p < 0.005). In the regression analysis, sclerostin was the best independent, negative predictor for BMD and TBS, while SIRT1 directly predicted TBS (p < 0.05). In conclusion, blood measurement of SIRT1 and sclerostin could represent a snapshot of the bone status that, taking into account the degree of adiposity, may reduce the interference of confounding factors in the interpretation of bone health parameters.
Sirtuin1 (SIRT1) 和骨硬化蛋白在脂肪组织和骨骼代谢中发挥重要作用。我们评估了循环 SIRT1 和骨硬化蛋白与骨量和骨质量的关系，同时考虑了肥胖程度。共纳入 66 名绝经前妇女（16 名体重不足、25 名体重正常和 25 名肥胖），年龄<50 岁。评估了血浆 SIRT1、骨硬化蛋白和 DXA 体成分（总脂肪量 (FM)、腹部内脏脂肪组织、瘦体重、骨小梁评分 (TBS) 和腰椎及股骨颈 (FN) 骨密度 (BMD))。肥胖患者的 SIRT1 和 TBS 值最低，骨硬化蛋白浓度最高；BMD 随 FM 和 BMI 增加而增加，与 SIRT1 呈负相关。骨硬化蛋白与 SIRT1 呈负相关 (ρ = −0.37, p = 0.002)。当脊柱 BMD、FN BMD 和 TBS 按 BMI 标准化时，与 SIRT1 呈正相关，与骨硬化蛋白呈负相关（p<0.005）。在回归分析中，骨硬化蛋白是 BMD 和 TBS 的最佳独立负预测因子，而 SIRT1 直接预测 TBS（p<0.05）。总之，SIRT1 和骨硬化蛋白的血液测量可以代表骨骼状况的快照，考虑到肥胖程度，可以减少对骨健康参数解释的混杂因素的干扰。
