Department of Animal Medicine and Surgery, University of Cordoba, Campus Universitario Rabanales, 14014 Cordoba, Spain.
Maimonides Biomedical Research Institute of Cordoba (IMIBIC), Reina Sofia University Hospital, University of Cordoba, 14004 Cordoba, Spain.
Nutrients. 2022 Feb 28;14(5):1041. doi: 10.3390/nu14051041.
Increased dietary acid load has a negative impact on health, particularly when renal function is compromised. Fibroblast growth factor 23 (FGF23) is a bone-derived hormone that is elevated during renal failure. The relationship between metabolic acidosis and FGF23 remains unclear. To investigate the effect of dietary acid load on circulating levels of FGF23, rats with normal renal function and with a graded reduction in renal mass (1/2 Nx and 5/6 Nx) received oral NH4Cl for 1 month. Acid intake resulted in a consistent decrease of plasma FGF23 concentrations in all study groups when compared with their non-acidotic control: 239.3 ± 13.5 vs. 295.0 ± 15.8 pg/mL (intact), 346.4 ± 19.7 vs. 522.6 ± 29.3 pg/mL (1/2 Nx) and 988.0 ± 125.5 vs. 2549.4 ± 469.7 pg/mL (5/6 Nx). Acidosis also decreased plasma PTH in all groups, 96.5 ± 22.3 vs. 107.3 ± 19.1 pg/mL, 113.1 ± 17.3 vs. 185.8 ± 22.2 pg/mL and 504.9 ± 75.7 vs. 1255.4 ± 181.1 pg/mL. FGF23 showed a strong positive correlation with PTH (r = 0.877, p < 0.0001) and further studies demonstrated that acidosis did not influence plasma FGF23 concentrations in parathyroidectomized rats, 190.0 ± 31.6 vs. 215 ± 25.6 pg/mL. In conclusion, plasma concentrations of FGF23 are consistently decreased in rats with metabolic acidosis secondary to increased acid intake, both in animals with intact renal function and with decreased renal function. The in vivo effect of metabolic acidosis on FGF23 appears to be related to the simultaneous decrease in PTH.
饮食酸负荷增加对健康有负面影响，尤其是在肾功能受损时。成纤维细胞生长因子 23（FGF23）是一种骨源性激素，在肾衰竭时升高。代谢性酸中毒与 FGF23 之间的关系尚不清楚。为了研究饮食酸负荷对循环 FGF23 水平的影响，肾功能正常和肾质量逐渐减少（1/2 Nx 和 5/6 Nx）的大鼠接受口服 NH4Cl 1 个月。与非酸中毒对照相比，所有研究组的饮食摄入导致血浆 FGF23 浓度持续下降：239.3±13.5 与 295.0±15.8 pg/mL（完整）、346.4±19.7 与 522.6±29.3 pg/mL（1/2 Nx）和 988.0±125.5 与 2549.4±469.7 pg/mL（5/6 Nx）。酸中毒还降低了所有组的血浆 PTH，96.5±22.3 与 107.3±19.1 pg/mL、113.1±17.3 与 185.8±22.2 pg/mL 和 504.9±75.7 与 1255.4±181.1 pg/mL。FGF23 与 PTH 呈强烈正相关（r=0.877，p<0.0001），进一步的研究表明，酸中毒不会影响甲状旁腺切除大鼠的血浆 FGF23 浓度，190.0±31.6 与 215±25.6 pg/mL。结论：由于酸摄入增加导致代谢性酸中毒，大鼠的血浆 FGF23 浓度持续下降，无论是在肾功能正常的动物还是肾功能下降的动物中都是如此。代谢性酸中毒对 FGF23 的体内影响似乎与 PTH 的同时下降有关。
