Vazquez-Agra Nestor, Marques-Afonso Ana-Teresa, Cruces-Sande Anton, Novo-Veleiro Ignacio, Lopez-Paz Jose-Enrique, Pose-Reino Antonio, Hermida-Ameijeiras Alvaro
Department of Internal Medicine, University Hospital of Santiago de Compostela, 15706 A Coruña, Spain.
Department of Biochemistry and Molecular Biology, University of Santiago de Compostela, 15782 A Coruña, Spain.
J Clin Med. 2022 Feb 25;11(5):1252. doi: 10.3390/jcm11051252.
We aimed to explore the influence that the circadian blood pressure (BP) profile could exert on the correlation between some inflammatory markers and hypertension-mediated organ damage (HMOD). This was a cross-sectional study that included patients with primary arterial hypertension older than 18 years old. We included some parameters of 24 h ambulatory blood pressure monitoring collection and several inflammatory markers, as follows: platelet count (PTC), erythrocyte sedimentation rate (ESR), ultrasensitive C-reactive-protein, ferritin, fibrinogen, and uric acid. Myocardial hypertrophy, albuminuria, carotid intima-media thicknesses and ankle brachial index were assessed as HMOD presentations. Individuals were divided into two groups: patients with and without HMOD. We included 522 patients (47% women, mean age of 54 years). Multivariate logistic regression analysis showed that male patients older than 50 years old with uric acid levels above 7 mg/dL, ESR higher than 20 mm/h, fibrinogen greater than 320 mg/dL and PTC lower than 275 × 103/µL were associated with HMOD (p < 0.05). The circadian BP profile (dipper versus non-dipper pattern) did reach neither statistical significance nor influence the odds ratio of those inflammatory markers for HMOD. We found that differences in some inflammatory markers between patients with and without HMOD were not explained by a different circadian BP profile.
我们旨在探讨昼夜血压（BP）模式对某些炎症标志物与高血压介导的器官损害（HMOD）之间相关性的影响。这是一项横断面研究，纳入了年龄超过18岁的原发性动脉高血压患者。我们纳入了24小时动态血压监测收集的一些参数以及几种炎症标志物，如下：血小板计数（PTC）、红细胞沉降率（ESR）、超敏C反应蛋白、铁蛋白、纤维蛋白原和尿酸。评估心肌肥厚、蛋白尿、颈动脉内膜中层厚度和踝臂指数作为HMOD的表现。个体被分为两组：有和没有HMOD的患者。我们纳入了522例患者（47%为女性，平均年龄54岁）。多因素逻辑回归分析显示，年龄超过50岁、尿酸水平高于7mg/dL、ESR高于20mm/h、纤维蛋白原大于320mg/dL且PTC低于275×10³/µL的男性患者与HMOD相关（p<0.05）。昼夜血压模式（勺型与非勺型）既未达到统计学意义，也未影响这些炎症标志物与HMOD的比值比。我们发现，有和没有HMOD的患者之间某些炎症标志物的差异不能用不同的昼夜血压模式来解释。
