Hermida-Ameijeiras Alvaro, Vazquez-Agra Nestor, Cruces-Sande Anton, Mendez-Alvarez Estefania, Soto-Otero Ramon, Lopez-Paz Jose-Enrique, Pose-Reino Antonio, Gonzalez-Quintela Arturo
Department of Internal Medicine, University Hospital of Santiago de Compostela, 15706 A Coruña, Spain.
Department of Psychiatry, Radiology, Public Health, Nursing and Medicine, University of Santiago de Compostela, 15782 A Coruña, Spain.
J Clin Med. 2023 Feb 18;12(4):1643. doi: 10.3390/jcm12041643.
To date, no model has jointly encompassed clinical, inflammatory, and redox markers with the risk of a non-dipper blood pressure (BP) profile. We aimed to evaluate the correlation between these features and the main twenty-four-hour ambulatory blood pressure monitoring (24-h ABPM) indices, as well as to establish a multivariate model including inflammatory, redox, and clinical markers for the prediction of a non-dipper BP profile. This was an observational study that included hypertensive patients older than 18 years. We enrolled 247 hypertensive patients (56% women) with a median age of 56 years. The results showed that higher levels of fibrinogen, tissue polypeptide-specific antigen, beta-2-microglobulin, thiobarbituric acid reactive substances, and copper/zinc ratio were associated with a higher risk of a non-dipper BP profile. Nocturnal systolic BP dipping showed a negative correlation with beta-globulin, beta-2-microglobulin, and gamma-globulin levels, whereas nocturnal diastolic BP dipping was positively correlated with alpha-2-globulin levels, and negatively correlated with gamma-globulin and copper levels. We found a correlation between nocturnal pulse pressure and beta-2-microglobulin and vitamin E levels, whereas the day-to-night pulse pressure gradient was correlated with zinc levels. Twenty-four-hour ABPM indices could exhibit singular inflammatory and redox patterns with implications that are still poorly understood. Some inflammatory and redox markers could be associated with the risk of a non-dipper BP profile.
迄今为止，尚无模型能将临床、炎症和氧化还原标志物与非勺型血压（BP）模式的风险综合起来。我们旨在评估这些特征与主要的24小时动态血压监测（24-h ABPM）指标之间的相关性，并建立一个包含炎症、氧化还原和临床标志物的多变量模型，用于预测非勺型BP模式。这是一项观察性研究，纳入了年龄超过18岁的高血压患者。我们招募了247名高血压患者（56%为女性），中位年龄为56岁。结果显示，纤维蛋白原、组织多肽特异性抗原、β2微球蛋白、硫代巴比妥酸反应性物质以及铜/锌比值水平较高与非勺型BP模式的较高风险相关。夜间收缩压下降幅度与β球蛋白、β2微球蛋白和γ球蛋白水平呈负相关，而夜间舒张压下降幅度与α2球蛋白水平呈正相关，与γ球蛋白和铜水平呈负相关。我们发现夜间脉压与β2微球蛋白和维生素E水平之间存在相关性，而昼夜脉压梯度与锌水平相关。24-h ABPM指标可能呈现出独特的炎症和氧化还原模式，其影响仍知之甚少。一些炎症和氧化还原标志物可能与非勺型BP模式的风险相关。
