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蓝光阻断疗法治疗双相情感障碍:研究与实践方向

Blue Light Blocking Treatment for the Treatment of Bipolar Disorder: Directions for Research and Practice.

作者信息

Mylona Ioanna, Floros Georgios D

机构信息

2nd Department of Ophthalmology, Aristotle University of Thessaloniki, 541 24 Thessaloniki, Greece.

2nd Department of Psychiatry, Aristotle University of Thessaloniki, 541 24 Thessaloniki, Greece.

出版信息

J Clin Med. 2022 Mar 2;11(5):1380. doi: 10.3390/jcm11051380.

DOI:10.3390/jcm11051380
PMID:35268469
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8911317/
Abstract

Recent results from a small number of clinical studies have resulted in the suggestion that the process of blocking the transmission of shorter-wavelength light ('blue light' with a wave length of 450 nm to 470 nm) may have a beneficial role in the treatment of bipolar disorder. This critical review will appraise the quality of evidence so far as to these claims, assess the neurobiology that could be implicated in the underlying processes while introducing a common set of research criteria for the field.

摘要

少数临床研究的近期结果表明,阻断较短波长光(波长为450纳米至470纳米的“蓝光”)的传播过程可能对双相情感障碍的治疗具有有益作用。这篇批判性综述将评估关于这些说法的现有证据质量,评估可能涉及潜在过程的神经生物学,同时为该领域引入一套通用的研究标准。

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本文引用的文献

1
Combined cortisol and melatonin measurements with detailed parameter analysis can assess the circadian rhythms in bipolar disorder patients.联合皮质醇和褪黑素测量并进行详细参数分析可以评估双相情感障碍患者的昼夜节律。
Brain Behav. 2021 Jul;11(7):e02186. doi: 10.1002/brb3.2186. Epub 2021 Jun 6.
2
Blue blocking glasses for the treatment of mania in an elderly patient: A case report with polysomnographic findings.蓝色阻挡眼镜治疗老年患者躁狂症:一例伴有多导睡眠图结果的病例报告
Bipolar Disord. 2021 Sep;23(6):367-639. doi: 10.1111/bdi.13051. Epub 2021 Feb 19.
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Chronobiologically informed inpatient milieu in psychiatric institutions.精神病院基于时间生物学的住院环境
Lancet Psychiatry. 2020 Dec;7(12):1013-1014. doi: 10.1016/S2215-0366(20)30459-4.
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Bipolar disorder: Trimodal age-at-onset distribution.双相障碍:三峰发病年龄分布。
Bipolar Disord. 2021 Jun;23(4):341-356. doi: 10.1111/bdi.13016. Epub 2020 Nov 3.
5
The evening light environment in hospitals can be designed to produce less disruptive effects on the circadian system and improve sleep.医院的夜间光环境可以设计成减少对生物钟系统的干扰,并改善睡眠。
Sleep. 2021 Mar 12;44(3). doi: 10.1093/sleep/zsaa194.
6
A double-blind, randomized, placebo-controlled trial of adjunctive blue-blocking glasses for the treatment of sleep and circadian rhythm in patients with bipolar disorder.双盲、随机、安慰剂对照试验研究辅助性使用蓝光阻断眼镜治疗双相情感障碍患者的睡眠和昼夜节律紊乱。
Bipolar Disord. 2020 Nov;22(7):739-748. doi: 10.1111/bdi.12912. Epub 2020 Apr 20.
7
Circadian Regulation of Immunity Through Epigenetic Mechanisms.生物钟通过表观遗传机制对免疫的调节。
Front Cell Infect Microbiol. 2020 Mar 13;10:96. doi: 10.3389/fcimb.2020.00096. eCollection 2020.
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Cortisol levels in unmedicated patients with unipolar and bipolar major depression using hair and saliva specimens.使用毛发和唾液样本检测未接受药物治疗的单相和双相重度抑郁症患者的皮质醇水平。
Int J Bipolar Disord. 2020 Mar 5;8(1):15. doi: 10.1186/s40345-020-0180-x.
9
Dynamics of ACTH and Cortisol Secretion and Implications for Disease.促肾上腺皮质激素(ACTH)和皮质醇分泌的动力学及其对疾病的影响。
Endocr Rev. 2020 Jun 1;41(3). doi: 10.1210/endrev/bnaa002.
10
Accelerated aging in bipolar disorder: A comprehensive review of molecular findings and their clinical implications.双相障碍的加速老化:分子研究结果及其临床意义的综合述评。
Neurosci Biobehav Rev. 2020 May;112:107-116. doi: 10.1016/j.neubiorev.2020.01.035. Epub 2020 Feb 1.