Natural and Medical Sciences Research Center, University of Nizwa, Birkat Al Mauz 616, Nizwa P.O. Box 33, Oman.
School of Health Science, University of Petroleum and Energy Studies, Dehradun 248007, India.
Molecules. 2022 Feb 24;27(5):1539. doi: 10.3390/molecules27051539.
Marine drugs are abundant in number, comprise of a diverse range of structures with corresponding mechanisms of action, and hold promise for the discovery of new and better treatment approaches for the management of several chronic diseases. There are huge reserves of natural marine biological compounds, as 70 percent of the Earth is covered with oceans, indicating a diversity of chemical entities on the planet. The marine ecosystems are a rich source of bioactive products and have been explored for lead drug molecules that have proven to be novel therapeutic targets. Over the last 70 years, many structurally diverse drug products and their secondary metabolites have been isolated from marine sources. The drugs obtained from marine sources have displayed an exceptional potential in the management of a wide array of diseases, ranging from acute to chronic conditions. A beneficial role of marine drugs in human health has been recently proposed. The current review highlights various marine drugs and their compounds and role in the management of chronic diseases such as cancer, diabetes, neurodegenerative diseases, and cardiovascular disorders, which has led to the development of new drug treatment approaches.
海洋药物数量丰富,具有多种多样的结构和相应的作用机制,有望为治疗多种慢性疾病找到新的更好的治疗方法。海洋生物资源丰富,地球表面 70%被海洋覆盖,这表明地球上存在着多种多样的化学物质。海洋生态系统是生物活性产物的丰富来源,人们已经从海洋中寻找具有新型治疗靶点的先导药物分子。在过去的 70 年中,已经从海洋来源中分离出了许多结构多样的药物产品及其次生代谢产物。从海洋来源获得的药物在治疗各种疾病方面表现出了非凡的潜力,包括急性疾病和慢性疾病。最近有人提出海洋药物对人类健康有益。本文重点介绍了各种海洋药物及其化合物在治疗癌症、糖尿病、神经退行性疾病和心血管疾病等慢性疾病中的作用,这些作用促使人们开发出了新的药物治疗方法。