Ylikorkala O, Mäkilä U M, Kääpä P, Viinikka L
Am J Obstet Gynecol. 1986 Aug;155(2):345-9. doi: 10.1016/0002-9378(86)90823-9.
Small doses of maternal acetylsalicylic acid have proved to prevent preeclampsia. To study the mechanism of this action of acetylsalicylic acid, healthy women ingested 100 mg (n = 13) or 500 mg (n = 14) of acetylsalicylic acid during labor at term. The fetal prostacyclin synthesis, as assessed by the production of 6-ketoprostaglandin F1 alpha (a metabolite of prostacyclin) by the umbilical artery, was reduced from 21.3 +/- 1.6 ng/gm/min of dry weight in the controls (n = 25, mean +/- SE) to 7.8 +/- 1.1 ng/ml/min (p less than 0.001) in infants of mothers receiving 500 mg of acetylsalicylic acid, but it was unchanged in infants with mothers receiving 100 mg of acetylsalicylic acid (19.5 +/- 2.3 ng/gm/min). Maternal ingestion of 500 mg of acetylsalicylic acid also was accompanied by reduced (p less than 0.10) urinary excretion of 6-ketoprostaglandin F1 alpha in neonates during the first 3 days of life. The fetal platelet thromboxane A2 synthesis, as assessed by the release of thromboxane B2 (a metabolite of thromboxane A2) during spontaneous clotting of the umbilical blood (63.4 +/- 4.2 pg/10(5) platelets, n = 22), was inhibited in infants born to mothers given 100 mg (14.0 +/- 3.7 pg/10(5) platelets, p less than 0.001) or 500 mg of acetylsalicylic acid (6.1 +/- 3.5 pg/10(5) platelets, p less than 0.001). The thromboxane B2 release by the umbilical artery (1.1 +/- 0.1 ng/gm/min, n = 13) also was decreased in infants of mothers receiving 500 mg of acetylsalicylic acid (0.57 +/- 0.1 ng/gm/min, n = 7, p less than 0.01). Thus a small dose of maternal acetylsalicylic acid (100 mg) inhibits only the fetoplacental thromboxane A2 but leaves prostacyclin production unaffected.
小剂量的母体乙酰水杨酸已被证明可预防先兆子痫。为研究乙酰水杨酸这一作用的机制，健康女性在足月分娩时摄入100毫克（n = 13）或500毫克（n = 14）的乙酰水杨酸。通过脐动脉产生6 - 酮前列腺素F1α（前列环素的一种代谢产物）来评估胎儿前列环素的合成，在对照组（n = 25，平均值±标准误）中，其水平为21.3±1.6纳克/克干重/分钟，而在接受500毫克乙酰水杨酸的母亲所生婴儿中降至7.8±1.1纳克/毫升/分钟（p<0.001），但在接受100毫克乙酰水杨酸的母亲所生婴儿中则未改变（19.5±2.3纳克/克干重/分钟）。母体摄入500毫克乙酰水杨酸还伴随着新生儿出生后前3天尿中6 - 酮前列腺素F1α排泄量减少（p<0.10）。通过脐血自然凝血过程中血栓素B2（血栓素A2的一种代谢产物）的释放来评估胎儿血小板血栓素A2的合成，在给予100毫克（14.0±3.7皮克/10⁵血小板，p<0.001）或500毫克乙酰水杨酸的母亲所生婴儿中受到抑制（6.1±3.5皮克/10⁵血小板，p<0.001）。接受500毫克乙酰水杨酸的母亲所生婴儿的脐动脉血栓素B2释放量（1.1±0.1纳克/克干重/分钟，n = 13）也降低（0.57±0.1纳克/克干重/分钟，n = 7，p<0.01）。因此，小剂量的母体乙酰水杨酸（100毫克）仅抑制胎儿 - 胎盘血栓素A2，但不影响前列环素的产生。
