Daud Muhammad Usama, Abbas Ghulam, Afzaal Muhammad, Naz Muhammad Yasin, Fatima Nazma Goher, Ghuffar Abdul, Irfan Muhammad, Mahnashi Mater H, Legutko Stanislaw, Petrů Jana, Kratochvíl Jiří, Niazi Usama Muhammad
Department of Physics, Faisalabad Campus, Riphah International University, Faisalabad 44000, Pakistan.
Department of Physics, University of Agriculture, Faisalabad 38040, Pakistan.
Materials (Basel). 2022 Feb 26;15(5):1786. doi: 10.3390/ma15051786.
The finite element analysis technique was used to investigate the suitability of silver nanorods, spheres, ellipsoids and core−shell structures for the hyperthermia treatment of cancer. The temperature of the silver nanostructures was raised from 42 to 46 °C, in order to kill the cancerous cells. The time taken by the nanostructures to attain this temperature, with external source heating, was also estimated. The heat transfer module in COMSOL Multiphysics was used for the finite element analysis of hyperthermia, based on silver nanostructures. The thermal response of different shapes of silver nanostructures was evaluated by placing them inside the spherical domain of the tumor tissue. The proposed geometries were heated at different time intervals. Optimization of the geometries was performed to achieve the best treatment temperature. It was observed that silver nanorods quickly attain the desired temperature, as compared to other shapes. The silver nanorods achieved the highest temperature of 44.3 °C among all the analyzed geometries. Moreover, the central volume, used to identify the thermal response, was the maximum for the silver nano-ellipsoids. Thermal equilibrium in the treatment region was attained after 0.5 μs of heating, which made these structures suitable for hyperthermia treatment.
采用有限元分析技术研究了银纳米棒、球体、椭球体和核壳结构用于癌症热疗的适用性。将银纳米结构的温度从42℃升高到46℃，以杀死癌细胞。还估算了在外部源加热的情况下，纳米结构达到该温度所需的时间。基于银纳米结构，利用COMSOL Multiphysics中的传热模块对热疗进行有限元分析。通过将不同形状的银纳米结构放置在肿瘤组织的球形区域内，评估其热响应。对所提出的几何形状在不同的时间间隔进行加热。对几何形状进行优化以达到最佳治疗温度。结果发现，与其他形状相比，银纳米棒能快速达到所需温度。在所有分析的几何形状中，银纳米棒达到的最高温度为44.3℃。此外，用于识别热响应的中心体积对于银纳米椭球体来说是最大的。加热0.5微秒后，治疗区域达到热平衡，这使得这些结构适用于热疗。
