用于磁热疗和药物递送的多功能壳聚糖-MnFe₂O纳米粒子的合成与表征
Synthesis and Characterization of Multifunctional Chitosan- MnFe₂O Nanoparticles for Magnetic Hyperthermia and Drug Delivery.
作者信息
Kim Dong-Hyun, Nikles David E, Brazel Christopher S
机构信息
Department of Chemical and Biological Engineering, Box 870203, The University of Alabama, Tuscaloosa, AL 35487-0203, USA.
Department of Chemistry and Center for Materials for Information Technology, Box 870336, The University of Alabama, Tuscaloosa, AL 35487, USA.
出版信息
Materials (Basel). 2010 Jul 13;3(7):4051-4065. doi: 10.3390/ma3074051.
Multifunctional nanoparticles composed of MnFe₂O₄ were encapsulated in chitosan for investigation of system to combine magnetically-triggered drug delivery and localized hyperthermia for cancer treatment with the previously published capacity of MnFe₂O₄ to be used as an efficient MRI contrast agent for cancer diagnosis. This paper focuses on the synthesis and characterization of magnetic MnFe₂O₄ nanoparticles, their dispersion in water and their incorporation in chitosan, which serves as a drug carrier. The surface of the MnFe₂O₄ nanoparticles was modified with meso-2,3-di-mercaptosuccinic acid (DMSA) to develop stable aqueous dispersions. The nanoparticles were coated with chitosan, and the magnetic properties, heat generation and hydrodynamic size of chitosan-coated MnFe₂O₄ were evaluated for various linker concentrations and in a range of pH conditions.
由MnFe₂O₄组成的多功能纳米颗粒被包裹在壳聚糖中，以研究一种结合磁触发药物递送和局部热疗用于癌症治疗的系统，同时利用MnFe₂O₄先前已公布的用作癌症诊断有效MRI造影剂的能力。本文重点关注磁性MnFe₂O₄纳米颗粒的合成与表征、它们在水中的分散情况以及它们在作为药物载体的壳聚糖中的掺入情况。用中-2,3-二巯基琥珀酸（DMSA）对MnFe₂O₄纳米颗粒的表面进行修饰，以形成稳定的水性分散体。纳米颗粒用壳聚糖包覆，并针对各种连接剂浓度和一系列pH条件评估了壳聚糖包覆的MnFe₂O₄的磁性、产热和流体动力学尺寸。
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