Nanji A A, French S W
Alcohol Clin Exp Res. 1986 Jun;10(3):271-3. doi: 10.1111/j.1530-0277.1986.tb05088.x.
Mortality from cirrhosis in many countries deviates markedly from that expected for a given per capita alcohol intake. We investigated the possibility that dietary factors might explain the deviation expected and actual mortality rates in different countries. Deviations from expected cirrhosis mortality was calculated as a percentage for 17 different countries, all of whom had carrier rates for hepatitis B virus of less than 2%. The percentage of deviation was correlated with dietary intake of saturated fat, polyunsaturated fat, cholesterol, and also with mortality from ischemic heart disease. The percentage of deviation correlated inversely with dietary cholesterol (r = -0.86, p 0.001) and saturated fat (r = -0.80, p 0.001) and positively with polyunsaturated fats (r = -0.55 p 0.05). This suggests that both saturated fat and cholesterol protect against alcoholic cirrhosis while polyunsaturated fats promote cirrhosis. The correlation between percentage of deviation and ischemic heart disease (r = -0.78, p 0.002) suggests that those factors that promote ischemic heart disease protect against alcoholic cirrhosis.
许多国家肝硬化导致的死亡率与根据人均酒精摄入量预期的死亡率有显著偏差。我们调查了饮食因素是否可以解释不同国家预期死亡率与实际死亡率之间的偏差。以百分比形式计算了17个不同国家肝硬化死亡率的偏差情况，所有这些国家的乙肝病毒携带率均低于2%。偏差百分比与饱和脂肪、多不饱和脂肪、胆固醇的饮食摄入量以及缺血性心脏病死亡率相关。偏差百分比与饮食胆固醇（r = -0.86，p < 0.001）和饱和脂肪（r = -0.80，p < 0.001）呈负相关，与多不饱和脂肪呈正相关（r = -0.55，p < 0.05）。这表明饱和脂肪和胆固醇都能预防酒精性肝硬化，而多不饱和脂肪会促进肝硬化。偏差百分比与缺血性心脏病之间的相关性（r = -0.78，p < 0.002）表明，那些促进缺血性心脏病的因素能预防酒精性肝硬化。
