College of Medicine, University of the Philippines Manila, Manila 1000, Philippines.
Division of Basic Science and Translational Research, Department of Obstetrics and Gynecology, The University of Texas Medical Branch at Galveston, Galveston, TX 77555, USA.
Int J Mol Sci. 2022 Feb 22;23(5):2411. doi: 10.3390/ijms23052411.
Preterm birth remains to be one of the most prevalent obstetric complications worldwide. Since there are multiple etiological factors associated with this disease process, an integrative literature search in PubMed and Scopus databases on possible mechanism of action and effect of bisphenols on exposure on human or animal placental samples in preterm birth was conducted. From 2332 articles on initial literature search, 63 studies were included for full data extraction. Altogether, several pathways were shown to be possibly affected by bisphenols, leading to dysregulations in structural and endocrine foundation in the placenta, potential induction of senescence and failure of decidualization in the decidua, and possible propagation of inflammation in the fetal membranes. Combined, these actions may eventually counteract bisphenol-induced relaxation of the myometrium and promote contractility alongside fetal membrane weakening. In totality, these individual impairments in gestation-critical processes may lead to failure of maintenance of pregnancy, and thus effecting preterm birth.
早产仍然是全球最常见的产科并发症之一。由于与该疾病过程相关的病因有很多，因此在 PubMed 和 Scopus 数据库中进行了综合文献检索，以查找双酚类物质对人类或动物胎盘样本早产暴露的可能作用机制和影响。在最初的文献检索中，有 2332 篇文章，其中 63 项研究被纳入进行全面数据提取。总的来说，有几个途径可能受到双酚类物质的影响，导致胎盘结构和内分泌基础失调，蜕膜中可能出现衰老和去分化失败，以及胎儿膜中炎症的可能传播。这些作用结合起来，可能最终会抵消双酚类物质引起的子宫平滑肌松弛，并促进子宫收缩和胎膜减弱。总的来说，这些妊娠关键过程中的个体损伤可能导致妊娠维持失败，从而导致早产。
