Department of Chemistry & CICECO, Aveiro Institute of Materials, University of Aveiro, Campus Universitário de Santiago, 3810-193 Aveiro, Portugal.
Instituto de Investigação e Inovação em Saúde (i3S), R. Alfredo Allen 208, 4200-135 Porto, Portugal.
Int J Mol Sci. 2022 Mar 5;23(5):2855. doi: 10.3390/ijms23052855.
After the serendipitous discovery of cisplatin, a platinum-based drug with chemotherapeutic effects, an incredible amount of research in the area of coordination chemistry has been produced. Other transition metal compounds were studied, and several new relevant metallodrugs have been synthetized in the past few years. This review is focused on coordination compounds with first-row transition metals, namely, copper, cobalt, nickel or manganese, or with zinc, which have potential or effective pharmacological properties. It is known that metal complexes, once bound to organic drugs, can enhance the drugs' biological activities, such as anticancer, antimicrobial or anti-inflammatory ones. NSAIDs are a class of compounds with anti-inflammatory properties used to treat pain or fever. NSAIDs' properties can be strongly improved when included in complexes using their compositional N and O donor atoms, which facilitate their coordination to metal ions. This review focuses on the research on this topic and on the promising or effective results that complexes of first-row transition metals and NSAIDs can exhibit.
顺铂作为一种具有化疗效果的铂类药物被偶然发现后，在配位化学领域产生了大量的研究。其他过渡金属化合物也得到了研究，并且在过去的几年中已经合成了几种新的相关金属药物。本篇综述主要关注具有第一过渡金属（如铜、钴、镍或锰）或锌的配位化合物，这些化合物具有潜在或有效的药理学性质。已知金属配合物与有机药物结合后可以增强药物的生物活性，如抗癌、抗菌或抗炎活性。非甾体抗炎药（NSAIDs）是一类具有抗炎特性的化合物，用于治疗疼痛或发热。当 NSAIDs 的组成 N 和 O 供体原子被包含在复合物中时，它们的性质可以得到极大的改善，这使得它们能够与金属离子配位。本篇综述主要关注这一课题的研究以及第一过渡金属和 NSAIDs 的配合物所表现出的有希望或有效的结果。
