Department of Chemistry, Hong Kong Baptist University, Kowloon Tong, Hong Kong, China.
Angew Chem Int Ed Engl. 2013 Jul 22;52(30):7666-82. doi: 10.1002/anie.201208414. Epub 2013 Jun 13.
The serendipitous discovery of the anticancer drug cisplatin cemented medicinal inorganic chemistry as an independent discipline in the 1960s. Luminescent metal complexes have subsequently been widely applied for sensing, bio-imaging, and in organic light-emitting diode applications. Transition-metal complexes possess a variety of advantages that make them suitable as therapeutics and as luminescent probes for biomolecules. It is thus highly desirable to develop new luminescent metal complexes that either interact with DNA through different binding modes or target alternative cellular machinery such as proteins as well as to provide a more effective means of monitoring disease progression. In this Review, we highlight recent examples of biologically active luminescent metal complexes that can target and probe a specific biomolecule, and offer insights into the future potential of these compounds for the investigation and treatment of human diseases.
顺铂抗癌药物的偶然发现使药用无机化学在 20 世纪 60 年代成为一个独立的学科。此后，发光金属配合物已被广泛应用于传感、生物成像和有机发光二极管应用。过渡金属配合物具有多种优势，使其适合作为治疗剂和生物分子的发光探针。因此，开发新的发光金属配合物是非常理想的，这些配合物可以通过不同的结合模式与 DNA 相互作用，或者靶向替代的细胞机制，如蛋白质，并提供更有效的监测疾病进展的手段。在这篇综述中，我们重点介绍了最近一些具有生物活性的发光金属配合物的例子，这些配合物可以靶向和探测特定的生物分子，并深入了解这些化合物在研究和治疗人类疾病方面的未来潜力。
