Fortunato Leonzio, Barone Selene, Bennardo Francesco, Giudice Amerigo
Associate Professor, School of Dentistry, Department of Health Sciences, Magna Graecia University of Catanzaro, Catanzaro, Italy.
Resident, School of Dentistry, Department of Health Sciences, Magna Graecia University of Catanzaro, Catanzaro, Italy.
J Oral Maxillofac Surg. 2018 Jul;76(7):1460-1463. doi: 10.1016/j.joms.2018.01.012. Epub 2018 Jan 31.
This report describes a case of local pyoderma gangrenosum that was treated with short-term immunosuppressive therapy and the topical application of platelet-rich fibrin (PRF). Medical treatment included oral corticosteroid therapy and topical treatment with PRF in solid and liquid form. This therapy initially led to the reduction of the ulcer's size and an improvement in symptoms, until the ulcer was completely healed after a few weeks. A relapse was treated with only the application of PRF to the affected tissue with excellent recovery. The efficacy of PRF as a guide for wound healing is a result of the continuous release of growth factors involved in tissue repair mechanisms. PRF has proved to be suitable for the management of facial pyoderma gangrenosum while allowing a reduction in systemic corticosteroid therapy. The ease of preparation, low cost, and outpatient use make PRF an optimal scaffold for tissue healing processes.
本报告描述了一例局部坏疽性脓皮病患者，采用短期免疫抑制治疗及局部应用富血小板纤维蛋白（PRF）进行治疗。药物治疗包括口服糖皮质激素治疗以及固体和液体形式的PRF局部治疗。这种治疗最初使溃疡面积缩小，症状改善，几周后溃疡完全愈合。复发时仅对受影响组织应用PRF治疗，恢复良好。PRF作为伤口愈合指导的有效性是参与组织修复机制的生长因子持续释放的结果。PRF已被证明适用于面部坏疽性脓皮病的治疗，同时可减少全身糖皮质激素治疗。PRF制备简便、成本低且可门诊使用，使其成为组织愈合过程的理想支架。
