Price P, Turner K J
Aust J Exp Biol Med Sci. 1986 Apr;64 ( Pt 2):127-35. doi: 10.1038/icb.1986.14.
Depressed IgG responses to ovalbumin administered with the inflammatory adjuvant, Al(OH)3, have previously been demonstrated in mice immunized 5 to 13 days after infection with Nematospiroides dubius, when the parasite is encysted in the intestinal mucosa or becoming established in the lumen. This report extends these findings to show that primary IgE and delayed-type hypersensitivity (DTH) responses, the generation of antigen-primed cells detectable in syngeneic irradiated recipients or in vitro and the recall of immunological memory are correspondingly impaired. Co-transfer experiments using irradiated recipients demonstrated weak suppressor activity in spleen cells from infected mice which was not attributable to T cells. The results suggest that N. dubius administered before immunization can impair the development of many classes of antigen-primed lymphocytes. The implications of this finding with respect to parasite survival are discussed.
先前已证明，在用炎症佐剂氢氧化铝（Al(OH)3）给予卵清蛋白时，感染Dubius线虫5至13天后免疫的小鼠中，IgG反应会受到抑制，此时寄生虫包囊在肠黏膜中或开始在肠腔中定植。本报告扩展了这些发现，表明初次IgE和迟发型超敏反应（DTH）、在同基因照射受体中或体外可检测到的抗原致敏细胞的产生以及免疫记忆的回忆也相应受损。使用照射受体的共转移实验表明，感染小鼠脾细胞具有较弱的抑制活性，这并非归因于T细胞。结果表明，免疫前给予Dubius线虫可损害许多类抗原致敏淋巴细胞的发育。讨论了这一发现对寄生虫存活的影响。
