Price P, Turner K J
Exp Parasitol. 1987 Feb;63(1):21-31. doi: 10.1016/0014-4894(87)90074-9.
Mice (C57BL) infected with the intestinal nematode Nematospiroides dubius showed depressed delayed type hypersensitivity responses to ovalbumin administered subcutaneously in Freund's complete adjuvant. IgG and IgM responses to this inoculum were unaffected. It is unlikely that the depression arose from impairment of the ear test response because responses to an extract of the adult parasite were measurable and ear testing with lipopolysaccharide yielded normal responses in infected mice. Furthermore, mice immunized on the day of infection responded normally, whilst long term infected mice ear challenged with antigen pulsed macrophages gave depressed responses. The in vitro proliferative responses of cells from the spleens and from the lymph nodes draining the site of immunization were enhanced marginally by N. dubius infection. Furthermore, these cells induced normal or elevated adoptive delayed-type hypersensitivity and IgG responses in irradiated recipients. These findings suggest that N. dubius does not compromise the development of ovalbumin specific T cells involved in a delayed type hypersensitivity response. Evidence for the induction of suppressor cells by N. dubius is discussed, and the findings are compared with results obtained with Nippostrongylus brasiliensis, a parasite which is rejected rapidly from the mouse.
感染肠道线虫杜氏新圆线虫（Nematospiroides dubius）的C57BL小鼠，对皮下注射于弗氏完全佐剂中的卵清蛋白表现出迟发型超敏反应受抑制。对该接种物的IgG和IgM反应未受影响。这种抑制不太可能源于耳部试验反应的损害，因为对成年寄生虫提取物的反应是可测量的，并且用脂多糖进行耳部试验时，感染小鼠的反应正常。此外，在感染当天免疫的小鼠反应正常，而长期感染的小鼠用抗原脉冲巨噬细胞进行耳部攻击时反应受到抑制。杜氏新圆线虫感染略微增强了来自脾脏和免疫部位引流淋巴结的细胞的体外增殖反应。此外，这些细胞在受照射的受体中诱导出正常或增强的过继性迟发型超敏反应和IgG反应。这些发现表明，杜氏新圆线虫不会损害参与迟发型超敏反应的卵清蛋白特异性T细胞的发育。文中讨论了杜氏新圆线虫诱导抑制细胞的证据，并将这些发现与用巴西日圆线虫（Nippostrongylus brasiliensis）获得的结果进行了比较，巴西日圆线虫是一种能从小鼠体内迅速被清除的寄生虫。
