Price P, Holt P G
Aust J Exp Biol Med Sci. 1986 Oct;64 ( Pt 5):399-413. doi: 10.1038/icb.1986.43.
The functional characteristics of peritoneal cells (PC's) acquired in response to infection with Nematospiroides dubius were studied to identify changes which could be associated with the high level, long-term survival of this parasite or explain its transient immunosuppressive properties. The number of cells in the peritoneal cavity increased steadily during the infection, and the population displayed a transient hyperresponsiveness to inflammatory stimulation. N. dubius did not affect the ability of antigen-pulsed PC's to induce humoral responses or delayed-type hypersensitivity (DTH) in primed recipients, but lymphoproliferative responses induced in vitro were depressed by PC's from infected donors. In addition, unpulsed PC's from N. dubius-infected mice depressed proliferative responses to parasite antigens by autologous mesenteric lymph node cells. These effects are attributable to increased lymphocytostatic activity in the PC's, which peaked one week after infection and correlated with the expansion of a population of large plastic-adherent vacuolated cells with elevated acid phosphatase activity (activated macrophages). Comparable inhibitory cells did not develop in the same period of time during a short-lived infection with Nippostrongylus brasiliensis.
研究了感染双睾旋尾线虫后获得的腹膜细胞（PC）的功能特性，以确定可能与该寄生虫的高水平、长期存活相关的变化，或解释其短暂的免疫抑制特性。感染期间腹腔内细胞数量稳步增加，并且该细胞群体对炎症刺激表现出短暂的高反应性。双睾旋尾线虫不影响抗原脉冲处理的PC在致敏受体中诱导体液反应或迟发型超敏反应（DTH）的能力，但来自感染供体的PC会抑制体外诱导的淋巴细胞增殖反应。此外，来自感染双睾旋尾线虫小鼠的未脉冲处理的PC会抑制自体肠系膜淋巴结细胞对寄生虫抗原的增殖反应。这些效应归因于PC中淋巴细胞抑制活性的增加，这种活性在感染后一周达到峰值，并与一群具有高酸性磷酸酶活性的大的塑料贴壁空泡化细胞（活化巨噬细胞）的扩增相关。在感染巴西日圆线虫的短期感染期间，同期未发育出类似的抑制细胞。
